A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
Skin conditioning agent
R-Clostridium Histolyticum Collagenase G Hexapeptide-40
A lab-made peptide that mimics a bacterial enzyme to encourage collagen renewal, but research is still early and mostly from the ingredient supplier.
Irritation
low
Source
synthetic
Skin-conditioning agent
R-Clostridium Histolyticum Collagenase H SH-Oligopeptide-60
A novel peptide inspired by a bacterial enzyme that may help break down old collagen to encourage new collagen production, but human research is very limited.
Irritation
moderate
Source
biotech
A copper-peptide complex that may help support collagen production and skin firmness, but more human studies are needed to confirm its effects.
Irritation
low
Source
semi-synthetic
A copper-peptide complex that may help improve skin firmness and reduce fine lines, but more human studies are needed.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help support collagen and skin repair, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
A copper-peptide complex that may help support collagen and skin repair, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
Skin-conditioning agent
R-(SH-POLYPEPTIDE-92 OLIGOPEPTIDE-159 SH-OLIGOPEPTIDE-1)
A synthetic peptide complex that may help improve skin firmness and reduce fine lines, but results vary and it works best over months of consistent use.
Irritation
low
Source
synthetic
A well-studied peptide that helps firm skin and reduce fine lines, but results are gradual and best for long-term use.
Irritation
low
Source
synthetic
A copper peptide that helps firm skin and reduce fine lines, but results take time and consistency.
Irritation
low
Source
synthetic
A synthetic copper peptide that may help support skin firmness and repair, but research is less extensive than for classic copper peptides.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften expression lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but results vary and it works best in a consistent routine.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce fine lines, with low irritation risk.
Irritation
low
Source
synthetic
A novel peptide-curcumin hybrid that may help firm skin and reduce fine lines, but research is still early.
Irritation
low
Source
semi-synthetic
A synthetic peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
Anti-aging
CYCLOTETRAPEPTIDE-24 AMINOCYCLOHEXANE CARBOXYLATE
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more independent research is needed.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce the appearance of fine lines and improve skin firmness, with a good safety profile for most skin types.
Irritation
low
Source
synthetic
A novel blend of a signaling peptide and a fruit enzyme that may support skin renewal, but research is limited and irritation is possible.
Irritation
moderate
Source
mixed
Decapeptide-17 is a lab-made peptide that may help firm skin and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Decapeptide-31 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce the look of fine lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and elastin for firmer, smoother skin, though human data is still limited.
Irritation
low
Source
synthetic
Decapeptide-36 is a lab-made peptide that may help support collagen production and improve skin firmness, but human studies are limited.
Irritation
low
Source
synthetic
Decapeptide-38 is a lab-made peptide that may help firm skin and reduce fine lines, but research is still limited compared to more established peptides.
Irritation
low
Source
synthetic
Decapeptide-39 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Decapeptide-40 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A lab-made peptide that may help support skin firmness and reduce fine lines, but human studies are still limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, with low irritation risk.
Irritation
low
Source
synthetic
A lab-made peptide with antioxidant-like modifications that may help firm skin, but human studies are still limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce the appearance of fine lines and support skin firmness, but more human studies are needed.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and improve skin firmness, but human studies are limited.
Irritation
low
Source
synthetic
A novel peptide-ingredient hybrid that may help support skin firmness, but research is still early and benefits are not yet proven in large human studies.
Irritation
low
Source
semi-synthetic
Anti-wrinkle agent
DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE
A synthetic peptide that temporarily softens expression wrinkles by calming muscle contractions, similar to a milder, topical version of neuromodulators.
Irritation
low
Source
synthetic
A lab-made peptide-niacin hybrid that may help firm skin and soften lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide-niacin hybrid that may help firm skin and reduce fine lines, but research is still limited compared to well-studied peptides.
Irritation
low
Source
synthetic
Antioxidant
Epigallocatechin Gallate, Biotin, Collagen, Mouse Fibroblast Conditioned Media
A multi-ingredient blend that combines antioxidant EGCG with biotin and collagen, plus mouse fibroblast conditioned media; promising but with limited human data and ethical considerations.
Irritation
low
Source
mixed
A synthetic peptide that mimics scorpion venom to temporarily relax facial muscles, offering a milder alternative to neurotoxin injections for smoothing expression lines.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed to confirm its effectiveness.
Irritation
low
Source
synthetic
Endo-1,2 is a synthetic peptide that may help support skin firmness, but independent research is limited.
Irritation
low
Source
synthetic
Anti-aging
Ethyl Carbazido Hyaluronate Acetyl Hexapeptide-8
A modern peptide-hyaluronic acid hybrid that aims to plump and firm skin with low irritation potential.
Irritation
low
Source
semi-synthetic
Humectant
Ethyl Carbazido Hyaluronate, rh-Polypeptide-7
A biotech blend that pairs a modified hyaluronic acid with a lab-made peptide to hydrate and support skin resilience, though long-term human data is still limited.
Irritation
low
Source
biotech
A lab-made peptide-ferulic hybrid that may help firm skin, but human studies are still limited.
Irritation
low
Source
synthetic
A newer synthetic peptide that may help firm skin and soften lines, but long-term research is still limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but research is still emerging and it works best as part of a broader anti-aging routine.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but human studies are still limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften wrinkles, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and skin repair, but human data is still limited.
Irritation
low
Source
synthetic
A novel biotech peptide that may help firm skin, but research is very limited and it's not a proven anti-aging powerhouse.
Irritation
low
Source
biotech
A lab-made peptide inspired by a sea creature that may help calm skin and strengthen its defenses, but human research is still very limited.
Irritation
low
Source
synthetic
Heptapeptide-38 is a synthetic peptide that may help improve skin firmness and reduce the appearance of fine lines, with low irritation risk.
Irritation
low
Source
synthetic
A peptide that mimics the action of botulinum toxin to soften expression lines, but with milder and temporary effects.
Irritation
low
Source
synthetic
Hexapeptide-10 is a synthetic peptide that may help support collagen and elastin for firmer, smoother skin, but research is still emerging.
Irritation
low
Source
synthetic
A novel hybrid of peptide and vitamin C that may support collagen and antioxidant defense, but research is still early.
Irritation
low
Source
semi-synthetic