A potent chemical that breaks down hair proteins, but carries a high risk of skin and eye irritation — best left to professional use.
Irritation
high
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A potent chemical that breaks down hair proteins, but carries a high risk of skin and eye irritation — best left to professional use.
Irritation
high
Source
synthetic
Calcium sulfide is an effective hair remover but can be harsh and irritating, especially for sensitive skin.
Irritation
high
Source
synthetic
Calcium Thioglycolate is a proven hair-removal ingredient, but it can irritate sensitive skin and has a strong odor.
Irritation
moderate
Source
synthetic
A potent depilatory chemical that dissolves hair but can irritate sensitive skin if left on too long.
Irritation
moderate
Source
synthetic
Ethyl Cysteinate HCl is an effective hair-softening ingredient in depilatory and straightening products, but it can be irritating and should be used with caution.
Irritation
moderate
Source
synthetic
Ethyl Thioglycolate is an effective hair-removal chemical but can be irritating and has a strong odor, so it requires careful formulation and use.
Irritation
high
Source
synthetic
An effective hair-removal chemical, but can be irritating and has a strong odor.
Irritation
moderate
Source
synthetic
Mercaptopropionic acid is a potent chemical used in professional hair treatments and depilatories, but it carries a high risk of skin and eye irritation and is not recommended for regular at-home use.
Irritation
high
Source
synthetic
Methyl thioglycolate is a potent chemical that breaks down hair protein, but it can cause skin irritation and burns if misused.
Irritation
high
Source
synthetic
Phenylthioglycolic acid is a synthetic depilatory ingredient that breaks down hair keratin, but it can be irritating and is not intended for leave-on skincare.
Irritation
moderate
Source
synthetic
Potassium sulfide is an effective depilatory but can be highly irritating to skin and eyes; use with caution and follow product instructions exactly.
Irritation
high
Source
synthetic
Effective for hair removal but can be irritating and has a strong odor; use with caution and follow instructions closely.
Irritation
high
Source
synthetic
Strontium thioglycolate is a common active in depilatory creams that dissolves hair, but it can be irritating and has a strong odor.
Irritation
moderate
Source
synthetic
Thiodiglycolic acid is a strong reducing agent used in professional hair treatments to alter curl or remove hair, but it can be irritating and is not for daily skincare.
Irritation
moderate
Source
synthetic