Ingredient review
Dipeptide Diaminobutyroyl Benzylamide Diacetate
INCI: DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE
A synthetic peptide that temporarily softens expression wrinkles by calming muscle contractions, similar to a milder, topical version of neuromodulators.
In plain English
This ingredient is a lab-made peptide that works like a very gentle, temporary muscle relaxant for your skin. When applied in a cream or serum, it can help soften the look of frown lines and crow's feet by reducing the intensity of facial muscle movements. It's often called 'Syn-Ake' because it mimics a compound found in temple viper venom, but it's completely safe and non-toxic.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Dipeptide Diaminobutyroyl Benzylamide Diacetate is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Dipeptide Diaminobutyroyl Benzylamide Diacetate.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
A synthetic tripeptide (a short chain of amino acids) that mimics the action of waglerin-1, a neuropeptide from the venom of the temple viper. It is designed to temporarily inhibit muscle contraction at the neuromuscular junction.
How it works
It binds to the same receptors on muscle cells that are normally activated by nerve signals. By competing with natural neurotransmitters, it reduces the strength of muscle contractions, which in turn softens the appearance of dynamic wrinkles caused by repeated facial expressions.
Pros
Mimics a potent natural peptide
It is inspired by a snake venom peptide but is completely safe and non-toxic, offering a novel approach to wrinkle reduction.
Targets expression lines
Specifically works on dynamic wrinkles caused by muscle movement, making it a good option for frown lines and crow's feet.
Cons and cautions
Temporary results
The effects wear off within hours to days after stopping use, so you need to apply it consistently to see ongoing benefits.
Limited depth of effect
It cannot penetrate as deeply as injectable treatments, so it is best for superficial lines rather than deep-set wrinkles.
Best for
- People looking for a topical anti-aging option to soften fine lines
- Those who prefer non-invasive skincare over injectables
Use caution if
- Individuals with very deep static wrinkles may not see significant improvement
Usage tips
Safety summary
Considered safe for topical use at typical cosmetic concentrations. Rare reports of mild irritation or allergic reaction. Avoid contact with eyes and broken skin.
Research notes
Clinical studies show a statistically significant reduction in wrinkle depth and surface area after 28 days of use, though results vary by individual. More independent research is needed to compare efficacy across different peptide formulations.
Common label clues
- Typical concentration
- 0.001% to 0.01%
- Regulatory status
- Approved as a cosmetic ingredient in the EU, US, and many other regions. Not classified as a drug.
- Common uses
- Anti-aging serums, Eye creams, Facial treatments
- Environmental note
- Synthesized in a lab, so it does not involve animal harvesting and has a relatively low environmental footprint compared to natural extracts.
Good to know
- Often listed under trade names like Syn-Ake or SYN®-AKE in ingredient lists.
- It is a water-soluble peptide, so it works best in water-based serums rather than oil-based products.
Common questions
What is Dipeptide Diaminobutyroyl Benzylamide Diacetate in beauty products?
This ingredient is a lab-made peptide that works like a very gentle, temporary muscle relaxant for your skin. When applied in a cream or serum, it can help soften the look of frown lines and crow's feet by reducing the intensity of facial muscle movements. It's often called 'Syn-Ake' because it mimics a compound found in temple viper venom, but it's completely safe and non-toxic.
What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do in a beauty product?
It binds to the same receptors on muscle cells that are normally activated by nerve signals. By competing with natural neurotransmitters, it reduces the strength of muscle contractions, which in turn softens the appearance of dynamic wrinkles caused by repeated facial expressions.
Is Dipeptide Diaminobutyroyl Benzylamide Diacetate safe for most people?
Considered safe for topical use at typical cosmetic concentrations. Rare reports of mild irritation or allergic reaction. Avoid contact with eyes and broken skin.
Who should be careful with Dipeptide Diaminobutyroyl Benzylamide Diacetate?
Individuals with very deep static wrinkles may not see significant improvement
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.