Tetrapeptide-5 is a gentle, lab-made peptide that may help firm skin and reduce under-eye puffiness, but results are subtle and not instant.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Tetrapeptide-5 is a gentle, lab-made peptide that may help firm skin and reduce under-eye puffiness, but results are subtle and not instant.
Irritation
low
Source
synthetic
Tetrapeptide-51 is a lab-made peptide that may help firm and smooth skin by supporting collagen, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-52 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-53 is a lab-made peptide that may help support collagen and firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-54 is a synthetic peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-55 is a lab-made peptide that may help support skin firmness and reduce the look of fine lines, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-56 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and it's less studied than more common peptides.
Irritation
low
Source
synthetic
A newer synthetic peptide that may help improve skin firmness and smoothness, but research is still limited.
Irritation
low
Source
synthetic
Tetrapeptide-57 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce wrinkles, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-58 is a lab-made peptide that may help improve skin firmness and smooth fine lines, but research is still limited compared to more established peptides.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-59 is a lab-made peptide that may help support collagen production and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but human studies are still limited.
Irritation
low
Source
synthetic
Tetrapeptide-6 is a gentle, lab-made peptide that may help reduce under-eye puffiness and dark circles by supporting microcirculation and soothing the skin.
Irritation
low
Source
synthetic
Tetrapeptide-61 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-62 is a lab-made peptide that may help support collagen production and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
Tetrapeptide-62 Norleucyl Oligopeptide-149
A lab-made peptide duo that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-63 is a lab-made peptide that may help support skin structure and reduce signs of aging, but research is still early.
Irritation
low
Source
synthetic
A lab-made peptide that may help improve skin firmness and smooth fine lines, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-64 is a lab-made peptide that may help support collagen and firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-65 is a lab-made peptide that may help support collagen and firm skin, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-67 is a promising synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-67 Dimer is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
A gentle, research-backed peptide that calms skin inflammation and supports collagen for a smoother, more resilient complexion.
Irritation
low
Source
synthetic
A lightweight silicone that gives a silky, non-greasy feel to products, but offers no active skin benefits.
Irritation
low
Source
synthetic
A behind-the-scenes helper that protects your skincare formulas from metal contamination, keeping them effective and stable.
Irritation
low
Source
synthetic
A behind-the-scenes helper that boosts cleansing power and prevents mineral buildup, but is generally safe in rinse-off formulas.
Irritation
low
Source
synthetic
A gentle, antioxidant-rich microalgae extract that helps soothe and protect the skin from environmental stress.
Irritation
low
Source
natural
Surfactant
Tetrasodium Dicarboxyethyl Stearyl Sulfosuccinamate
A gentle, sulfate-free surfactant that cleanses effectively with low irritation potential, ideal for sensitive skin.
Irritation
low
Source
synthetic
A gentle, biodegradable chelating agent that protects your skincare formulas from metal contamination without the harshness of older alternatives.
Irritation
low
Source
synthetic
A mild, amino-acid-based surfactant that cleanses without stripping the skin barrier.
Irritation
low
Source
semi-synthetic
Tetrasodium EDTA is a safe, widely used chelating agent that helps your skincare products stay stable and effective by neutralizing hard water minerals.
Irritation
low
Source
synthetic
A gentle chelating agent that helps preserve product freshness and boosts the effectiveness of other ingredients by binding to unwanted metals.
Irritation
low
Source
synthetic
A gentle, biodegradable alternative to EDTA that protects your skincare formulas from metal-induced degradation.
Irritation
low
Source
semi-synthetic
A gentle, biodegradable chelating agent that boosts formula stability and skin feel without the concerns associated with traditional EDTA.
Irritation
low
Source
synthetic
A behind-the-scenes helper that keeps your products stable and effective by binding unwanted minerals.
Irritation
low
Source
synthetic
Antioxidant
Tetrasodium Tetracarboxymethyl Naringeninchalcone
A gentle, water-soluble antioxidant derived from citrus that helps calm skin and fight free radical damage.
Irritation
low
Source
semi-synthetic
A gentle botanical extract with antioxidant potential, but research on its skincare benefits is still limited.
Irritation
low
Source
natural
Teupolioside is a gentle plant antioxidant that may help calm skin and defend against environmental stress, though research is still early.
Irritation
low
Source
natural
Texas cedarwood oil adds a warm, woody scent to skincare but can be irritating for sensitive skin if used at high concentrations.
Irritation
moderate
Source
natural
A gentle, antioxidant-rich plant extract that may help soothe and protect skin, but research is still emerging.
Irritation
low
Source
natural
A gentle, algae-derived extract that may help protect skin from environmental stress and support hydration, though research is still early.
Irritation
low
Source
natural
A gentle marine extract that helps hydrate and calm the skin, with promising antioxidant potential.
Irritation
low
Source
natural
A gentle marine algae extract that helps hydrate skin and protect against environmental stress, though research is still emerging.
Irritation
low
Source
natural
A gentle, antioxidant-rich marine ferment that helps hydrate and protect the skin, but research is still emerging.
Irritation
low
Source
biotech
A gentle lichen extract with antioxidant potential, but research is still early and benefits are not yet proven in humans.
Irritation
low
Source
natural
A natural sweetener and mild antioxidant from a West African fruit, used mainly for flavor in lip products rather than for skin benefits.
Irritation
low
Source
natural
Theanine is a gentle, calming amino acid that helps soothe stressed skin and fight environmental damage.
Irritation
low
Source
natural
A gentle fern extract that may help protect skin from environmental stress, but research is still early.
Irritation
low
Source
natural
A synthetic antioxidant that may help protect skin from environmental stress, but research is still limited compared to more established ingredients.
Irritation
low
Source
synthetic
A gentle antioxidant from cacao that may help soothe skin and support a firmer appearance.
Irritation
low
Source
natural
Theophylline may temporarily tighten skin and improve circulation, but results are modest and it can cause irritation for sensitive skin.
Irritation
moderate
Source
synthetic
Soothing agent
FLAVOBACTERIUM THERMOPHILUM FERMENT FILTRATE LYSATE
A gentle, biotech ingredient from heat-loving bacteria that may help calm irritation and support the skin barrier.
Irritation
low
Source
biotech
Anti-aging agent
Thermotoga Maritima Polypeptide-1, Oligopeptide-105, Oligopeptide-106, Hexapeptide-40
A biotech peptide blend that may help support skin firmness and resilience, though human studies are limited.
Irritation
low
Source
biotech
A biotech peptide from an extremophile microbe that may help skin cope with environmental stress, but human research is still limited.
Irritation
low
Source
biotech
A gentle enzyme exfoliant from a heat-loving microbe that helps soften and smooth skin without harsh scrubbing.
Irritation
low
Source
biotech
Thiabendazole is an effective preservative but is rarely used in modern skincare; it may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
A gentle, fat-soluble form of vitamin B1 that may help calm skin and support antioxidant defenses, though research in cosmetics is still limited.
Irritation
low
Source
semi-synthetic
A bioactive form of vitamin B1 that may help protect skin from oxidative stress and support a healthy-looking complexion, though research in topical skincare is still emerging.
Irritation
low
Source
semi-synthetic