Ingredient review
Tetrasodium Tetracarboxymethyl Naringeninchalcone
INCI: Tetrasodium Tetracarboxymethyl Naringeninchalcone
A gentle, water-soluble antioxidant derived from citrus that helps calm skin and fight free radical damage.
In plain English
This ingredient is a modified version of a compound found in citrus fruits (naringenin chalcone). It has been chemically altered to dissolve better in water, making it easier to use in skincare products. It works mainly as an antioxidant, meaning it helps protect your skin from damage caused by pollution, UV rays, and other environmental stressors. It also has soothing properties, which can help reduce redness or irritation.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- semi synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Tetrasodium Tetracarboxymethyl Naringeninchalcone is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Tetrasodium Tetracarboxymethyl Naringeninchalcone.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
A semi-synthetic, water-soluble derivative of naringenin chalcone, a flavonoid found in citrus peels. The tetracarboxymethyl modification improves stability and solubility in water-based formulas.
How it works
As an antioxidant, it neutralizes free radicals (unstable molecules that can damage skin cells). It also inhibits certain inflammatory pathways, helping to calm irritated skin. Its water solubility allows it to be easily incorporated into serums and lightweight moisturizers.
Pros
Gentle on skin
Low irritation risk makes it suitable for sensitive skin types, unlike some stronger antioxidants that can sting or cause redness.
Water-soluble and lightweight
Easily formulated into serums and gels without a greasy feel, making it ideal for oily or combination skin.
Cons and cautions
Moderate evidence
While promising, most research is lab-based or small-scale; large human trials are still limited compared to well-studied antioxidants like vitamin C.
Potential allergen concern
Derived from citrus, so those with citrus allergies may want to patch test first, though the modification reduces allergenic potential.
Best for
- People with sensitive or reactive skin
- Anyone looking for a gentle antioxidant booster
- Those who prefer water-based, lightweight skincare
Use caution if
- Individuals with known citrus allergies (though the derivative is highly modified, caution is advised)
- Those seeking a very high-potency antioxidant (may need a stronger option)
Usage tips
Safety summary
Considered safe for cosmetic use at typical concentrations. Low irritation and comedogenic risk. Patch testing recommended for those with citrus allergies.
Research notes
In vitro and some small human studies show antioxidant and anti-inflammatory activity. More large-scale human trials are needed to confirm long-term benefits.
Common label clues
- Typical concentration
- 0.1% to 1%
- Regulatory status
- Approved for use in cosmetics in the EU, US, and other major markets. No specific restrictions beyond general cosmetic safety requirements.
- Common uses
- Serums, Moisturizers, Eye creams, Sunscreens
- Environmental note
- Derived from citrus byproducts, which are renewable resources. The chemical modification process has a moderate environmental footprint.
Good to know
- This ingredient is often listed near the end of ingredient lists due to low use concentrations.
- It pairs well with other antioxidants like vitamin E for enhanced protection.
Common questions
What is Tetrasodium Tetracarboxymethyl Naringeninchalcone in beauty products?
This ingredient is a modified version of a compound found in citrus fruits (naringenin chalcone). It has been chemically altered to dissolve better in water, making it easier to use in skincare products. It works mainly as an antioxidant, meaning it helps protect your skin from damage caused by pollution, UV rays, and other environmental stressors. It also has soothing properties, which can help reduce redness or irritation.
What does Tetrasodium Tetracarboxymethyl Naringeninchalcone do in a beauty product?
As an antioxidant, it neutralizes free radicals (unstable molecules that can damage skin cells). It also inhibits certain inflammatory pathways, helping to calm irritated skin. Its water solubility allows it to be easily incorporated into serums and lightweight moisturizers.
Is Tetrasodium Tetracarboxymethyl Naringeninchalcone safe for most people?
Considered safe for cosmetic use at typical concentrations. Low irritation and comedogenic risk. Patch testing recommended for those with citrus allergies.
Who should be careful with Tetrasodium Tetracarboxymethyl Naringeninchalcone?
Individuals with known citrus allergies (though the derivative is highly modified, caution is advised) Those seeking a very high-potency antioxidant (may need a stronger option)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.