Methenamine is a synthetic preservative that works by slowly releasing formaldehyde, which can be effective but raises concerns for skin sensitivity and long-term safety.
Irritation
moderate
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Methenamine is a synthetic preservative that works by slowly releasing formaldehyde, which can be effective but raises concerns for skin sensitivity and long-term safety.
Irritation
moderate
Source
synthetic
Methenammonium Chloride is a synthetic preservative that helps keep products fresh but may cause irritation in sensitive skin.
Irritation
moderate
Source
synthetic
A gentle silicone powder that gives a silky feel and helps control shine without clogging pores.
Irritation
low
Source
synthetic
Methionine is a gentle antioxidant amino acid that helps protect skin from environmental stress and supports natural repair processes.
Irritation
low
Source
natural
A synthetic peptide blend that may help firm skin and soften fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-75 SH-POLYPEPTIDE-8
A lab-made peptide duo that may help smooth wrinkles and improve skin firmness, but results vary and more human studies are needed.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-1 SR-JELLYFISH POLYPEPTIDE-1
A novel peptide blend that may support skin firmness and hydration, but human research is very limited.
Irritation
low
Source
semi-synthetic
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-2 DECAPEPTIDE-40
A synthetic peptide blend that may help support collagen and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and repair, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help firm skin and soften fine lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40
A synthetic peptide blend that may help support skin firmness and reduce fine lines, but human research is still limited.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-13 DECAPEPTIDE-40
A synthetic peptide blend that may help firm skin and soften lines, but human research is still limited.
Irritation
low
Source
synthetic
Anti-Aging Agent
METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40
A lab-made peptide blend that may help firm skin and soften lines, but human research is still limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and smooth fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-31 DECAPEPTIDE-40)
A synthetic peptide blend that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-59 DECAPEPTIDE-40
A lab-made peptide blend that may help signal skin to look firmer and smoother, but long-term human data is still limited.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-60 DECAPEPTIDE-40)
A synthetic peptide blend that may help firm skin and soften wrinkles, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-76 DECAPEPTIDE-40
A synthetic peptide complex that may help signal skin to appear firmer and smoother, but research is still emerging.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-8 DECAPEPTIDE-40)
A synthetic peptide blend that may help firm skin and soften lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but human data is still limited.
Irritation
low
Source
synthetic
Skin conditioning agent
METHIONYL SH-POLYPEPTIDE-9 DECAPEPTIDE-40
A lab-made peptide that may help firm skin and soften lines, but human studies are limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help signal skin to look firmer and smoother, but human studies are limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and firm skin, but human studies are still limited.
Irritation
low
Source
synthetic
Skin-conditioning agent
METHIONYL SH-POLYPEPTIDE-7 ALANYL SR-SPIDER OLIGOPEPTIDE-1
A lab-made peptide blend that mimics spider silk to help skin feel firmer, but research is still early and benefits are not guaranteed.
Irritation
low
Source
synthetic
Methotrexate is a potent prescription drug, not a cosmetic ingredient, and should never be used in skincare products.
Irritation
high
Source
synthetic
A lab-made peptide that may help smooth wrinkles and firm skin, but research is still early and it's not a replacement for proven anti-aging ingredients.
Irritation
low
Source
synthetic
Film Former
METHOXY AMODIMETHICONE/SILSESQUIOXANE COPOLYMER
A silicone polymer that forms a flexible, breathable film for long-lasting wear and water resistance without heavy buildup.
Irritation
low
Source
synthetic
A synthetic fragrance ingredient that adds a pleasant scent but may cause irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic scent ingredient that adds a fresh note but may cause irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic fragrance ingredient that provides a fresh scent but may cause irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic scent ingredient that adds a fresh note but offers no skincare benefit; safe at low levels but may cause sensitivity in some people.
Irritation
low
Source
synthetic
A synthetic fragrance ingredient with antioxidant properties, generally considered safe at low concentrations but may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
A synthetic fragrance compound that adds a nutty, earthy scent to products but offers no skincare benefits.
Irritation
low
Source
synthetic
Methoxy PEG-10 is a gentle, water-attracting polymer that helps keep skin hydrated and improves product texture, but it is synthetic and may be a concern for those avoiding PEGs.
Irritation
low
Source
synthetic
A silicone polymer that forms a breathable, water-resistant film for smoother skin and longer wear.
Irritation
low
Source
synthetic
A synthetic silicone polymer that improves product feel and spreadability without heavy residue.
Irritation
low
Source
synthetic
A synthetic humectant that helps dissolve other ingredients and retain moisture, but offers no unique benefits over gentler alternatives.
Irritation
low
Source
synthetic
A gentle, stabilized vitamin C derivative that brightens skin and fights free radicals with minimal irritation.
Irritation
low
Source
semi-synthetic
A synthetic polymer that helps products spread smoothly and leaves a flexible, non-sticky film on skin or hair.
Irritation
low
Source
synthetic
A gentle, PEG-modified retinoid that may support smoother skin with less irritation than traditional retinol, but research is still emerging.
Irritation
low
Source
semi-synthetic
A synthetic silicone polymer that helps products spread smoothly and resist water, but may feel heavy on some skin types.
Irritation
low
Source
synthetic
A gentle, water-binding ingredient that helps keep products stable and skin hydrated, but its synthetic origin may not appeal to everyone.
Irritation
low
Source
synthetic
A gentle, water-attracting polymer that helps keep skin hydrated without clogging pores, but may not suit those avoiding all PEGs.
Irritation
low
Source
synthetic
A gentle synthetic polymer that helps products feel silky, spread evenly, and stay put without clogging pores.
Irritation
low
Source
synthetic
A gentle, water-soluble derivative of birch bark betulin that helps condition skin and form a light protective film, but research on its specific benefits is still limited.
Irritation
low
Source
semi-synthetic
A gentle film-forming ingredient derived from birch bark that helps skin feel smooth and protected, but research on its benefits is still limited.
Irritation
low
Source
semi-synthetic
A synthetic polymer that helps products spread smoothly, feel silky, and stay put without clogging pores.
Irritation
low
Source
synthetic
A synthetic humectant that helps keep skin hydrated and improves product texture, but may be less eco-friendly due to its PEG origin.
Irritation
low
Source
synthetic
A synthetic emulsifier that helps blend oil and water in cleansers, but may not suit those avoiding PEGs.
Irritation
low
Source
synthetic
A synthetic film-former that may help other ingredients stick to skin, but its large molecule size limits penetration and its safety data is still emerging.
Irritation
low
Source
synthetic
A synthetic polymer that helps products spread smoothly and form a light, flexible film on skin or hair, but its high molecular weight limits skin penetration and its safety data is still emerging.
Irritation
low
Source
synthetic
A gentle, stabilized vitamin C derivative that brightens and protects skin without the sting of pure L-ascorbic acid.
Irritation
low
Source
semi-synthetic
A gentle, semi-synthetic emollient that mimics natural skin lipids to soften and smooth skin without clogging pores.
Irritation
low
Source
semi-synthetic
Emollient
METHOXY PEG-8 DIMETHYLSILYLETHYL TRIMETHYLSILANE
A gentle silicone that improves product texture and leaves skin feeling smooth without clogging pores.
Irritation
low
Source
synthetic
Film Former
METHOXY PEG-17/METHOXY PEG-11/HDI ISOCYANURATE TRIMER CROSSPOLYMER
A synthetic polymer that helps products spread smoothly and stay put, but offers no active skincare benefit.
Irritation
low
Source
synthetic