Ingredient review
Methionyl SH-Polypeptide-92
INCI: METHIONYL SH-POLYPEPTIDE-92
A lab-made peptide that may help signal skin to look firmer and smoother, but human studies are limited.
In plain English
This is a synthetic peptide, which is a short chain of amino acids (the building blocks of proteins). In skincare, peptides are used as signaling molecules—they can tell skin cells to behave a certain way, like producing more collagen or elastin. Methionyl SH-Polypeptide-92 is a specific peptide designed to support skin structure, potentially making skin feel firmer and reducing the look of fine lines over time. Because it's a large molecule, it needs help penetrating the skin, so it's often paired with delivery systems in formulas.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is still emerging, so marketing claims deserve extra caution.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- emerging
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Methionyl SH-Polypeptide-92 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Methionyl SH-Polypeptide-92.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
A synthetic peptide engineered in a lab, consisting of a chain of amino acids including methionine. It belongs to a class of cosmetic ingredients called signal peptides.
How it works
It is thought to mimic natural peptide signals in the skin, encouraging fibroblasts (skin cells) to produce more collagen and other supportive proteins. This can help improve skin firmness and reduce the appearance of wrinkles with consistent use.
Pros
Gentle anti-aging support
Peptides like this one are generally well-tolerated and can be a good option for those with sensitive skin who want to support collagen without irritation.
Targeted signaling
As a signal peptide, it works with your skin's natural processes rather than forcing a reaction, which can lead to more natural-looking results over time.
Cons and cautions
Limited evidence
There are few published human studies specifically on Methionyl SH-Polypeptide-92, so its effectiveness is less certain compared to more researched peptides.
Penetration challenges
Peptides are large molecules and may not easily penetrate the skin's barrier. The final product's formulation (e.g., inclusion of penetration enhancers) is critical for any benefit.
Best for
- People looking for anti-aging support without harsh actives
- Those with sensitive skin who tolerate peptides well
Use caution if
- Anyone allergic to synthetic peptides (rare)
- Those expecting immediate, dramatic results
Usage tips
Safety summary
Methionyl SH-Polypeptide-92 is considered safe for topical cosmetic use at typical concentrations. There are no known significant safety concerns, though individual sensitivity is always possible. Always patch test new products.
Research notes
Research on this specific peptide is limited. Most evidence comes from studies on similar signal peptides, which show potential for collagen support. More direct human trials are needed to confirm its efficacy.
Common label clues
- Typical concentration
- Typically used at very low concentrations, often below 1%
- Regulatory status
- Approved for use in cosmetics in the US, EU, and many other regions. It is not classified as a drug ingredient.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- As a synthetic peptide, it is produced in a lab, which avoids harvesting from animal or plant sources. Its environmental impact is considered low due to the small quantities used.
Good to know
- Peptides are often listed near the end of an ingredient list because they are effective at very low concentrations.
- This ingredient is not the same as growth factors or hormones—it is a cosmetic ingredient, not a drug.
Common questions
What is Methionyl SH-Polypeptide-92 in beauty products?
This is a synthetic peptide, which is a short chain of amino acids (the building blocks of proteins). In skincare, peptides are used as signaling molecules—they can tell skin cells to behave a certain way, like producing more collagen or elastin. Methionyl SH-Polypeptide-92 is a specific peptide designed to support skin structure, potentially making skin feel firmer and reducing the look of fine lines over time. Because it's a large molecule, it needs help penetrating the skin, so it's often paired with delivery systems in formulas.
What does Methionyl SH-Polypeptide-92 do in a beauty product?
It is thought to mimic natural peptide signals in the skin, encouraging fibroblasts (skin cells) to produce more collagen and other supportive proteins. This can help improve skin firmness and reduce the appearance of wrinkles with consistent use.
Is Methionyl SH-Polypeptide-92 safe for most people?
Methionyl SH-Polypeptide-92 is considered safe for topical cosmetic use at typical concentrations. There are no known significant safety concerns, though individual sensitivity is always possible. Always patch test new products.
Who should be careful with Methionyl SH-Polypeptide-92?
Anyone allergic to synthetic peptides (rare) Those expecting immediate, dramatic results
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.