A synthetic peptide that signals skin to build more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A synthetic peptide that signals skin to build more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
SH-Polypeptide-111 is a synthetic peptide that may help reduce fine lines and support firmer-looking skin, but human studies are limited.
Irritation
low
Source
synthetic
SH-Polypeptide-14 is a lab-made peptide that may help reduce fine lines by signaling skin to produce more collagen.
Irritation
low
Source
synthetic
A promising synthetic peptide that may help reduce fine lines and improve skin firmness, but more human studies are needed to confirm its effectiveness.
Irritation
low
Source
synthetic
SH-Polypeptide-28 is a synthetic peptide that may help reduce fine lines and improve skin firmness by signaling collagen production, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce fine lines and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
SH-Polypeptide-32 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
SH-Polypeptide-41 is a lab-made peptide that may help reduce fine lines by encouraging the skin to produce more collagen, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce fine lines and improve skin firmness, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
SH-Polypeptide-56 is a lab-made peptide that may help soften expression lines, but research is still early and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce fine lines and support firmer-looking skin, but human studies are limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and reduce fine lines, but human research is still limited.
Irritation
low
Source
synthetic
SH-Polypeptide-75 is a lab-made peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with minimal irritation risk.
Irritation
low
Source
synthetic
A promising synthetic peptide that may help firm skin and reduce fine lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness with low irritation risk.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften expression lines, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften fine lines, but human studies are still limited.
Irritation
low
Source
synthetic
A lab-made peptide that aims to mimic the skin-firming effects of shikimic acid, but clinical data is still limited.
Irritation
low
Source
semi-synthetic
A lab-made peptide that may help firm skin and soften lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften wrinkles, with low irritation potential.
Irritation
low
Source
synthetic
A lab-made peptide that may help smooth wrinkles and improve skin firmness, but human studies are still limited.
Irritation
low
Source
synthetic
A synthetic peptide trio that signals skin to produce more collagen, but results are gradual and not instant.
Irritation
low
Source
synthetic
A gentle peptide from silkworm silk that may help support skin firmness and hydration, though research is still emerging.
Irritation
low
Source
natural
A lab-made peptide that mimics snail proteins, showing early promise for skin firmness and wrinkle reduction, but human studies are still limited.
Irritation
low
Source
synthetic
Anti-aging agent
Sodium Formylhippurate Trifluoroacetylisobutyl Dipeptide-42 Amide
A synthetic peptide that may help reduce fine lines by supporting collagen, but research is still limited and it's less studied than more common peptides.
Irritation
low
Source
synthetic
A gentle, plant-derived peptide that may help support skin firmness and hydration with minimal irritation risk.
Irritation
low
Source
natural
SR-Dog Polypeptide-1 is a synthetic peptide that may support collagen production and skin firmness, but human research is very limited.
Irritation
low
Source
synthetic
A gentle peptide that may help improve skin firmness and texture over time, but results are subtle and require consistent use.
Irritation
low
Source
synthetic
A lab-made peptide inspired by spider silk that may help firm and smooth skin, but human research is still limited.
Irritation
low
Source
synthetic
A lab-made peptide inspired by spider silk that may help temporarily firm and smooth skin, but human research is very limited.
Irritation
low
Source
biotech
A lab-made peptide inspired by spider silk that may help support skin firmness, but human research is still limited.
Irritation
low
Source
synthetic
A lab-made peptide that mimics spider silk to temporarily tighten and smooth skin, but long-term anti-aging evidence is still limited.
Irritation
low
Source
synthetic
A gentle, hybrid peptide-vitamin C ingredient that may support brightness and collagen, but research is still early.
Irritation
low
Source
semi-synthetic
A novel synthetic peptide inspired by cone snail venom, marketed as a neurotoxin-like anti-wrinkle ingredient, but with very limited human safety and efficacy data.
Irritation
moderate
Source
synthetic
A synthetic peptide complex that may support skin firmness and repair, but human studies are limited.
Irritation
low
Source
synthetic
Anti-wrinkle agent
T-BUTYLCHROMENAMIDO BENZYL METHANESULFONAMIDE
A synthetic peptide-like compound that aims to relax expression lines, but clinical evidence is still limited compared to more established alternatives.
Irritation
low
Source
synthetic
Anti-aging agent
TETRACARBOXYMETHYL DIHYDROXYBENZOYL DIPEPTIDE-12
A synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but more human studies are needed to confirm its effectiveness.
Irritation
low
Source
synthetic
Anti-wrinkle agent
TETRADECYL AMINOBUTYROYLVALYLAMINOBUTYRIC UREA TRIFLUOROACETATE
A synthetic peptide that mimics the effects of certain neuropeptides to soften expression lines, but results are subtle and temporary.
Irritation
low
Source
synthetic
Tetrapeptide-1 is a gentle peptide that may help support collagen and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Tetrapeptide-15 is a synthetic peptide that may help support collagen and reduce the appearance of fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Tetrapeptide-2 is a gentle peptide that may help firm skin and reduce under-eye bags, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften fine lines, but results are subtle and require consistent use.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, with good tolerability for most skin types.
Irritation
low
Source
synthetic
Tetrapeptide-3 is a gentle peptide that may help firm skin and reduce under-eye puffiness, but research is still emerging.
Irritation
low
Source
synthetic
Tetrapeptide-36 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A gentle peptide that may help reduce under-eye puffiness and support firmer-looking skin over time.
Irritation
low
Source
synthetic
Tetrapeptide-40 is a lab-made peptide that may help support skin structure and reduce signs of aging, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-41 is a lab-made peptide that may help support skin firmness and smoothness, but research is still early and results vary.
Irritation
low
Source
synthetic
A lab-made peptide fused with a form of vitamin B3, aimed at supporting skin structure, but with limited independent research.
Irritation
low
Source
synthetic
Tetrapeptide-46 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-48 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-49 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-5 is a gentle, lab-made peptide that may help firm skin and reduce under-eye puffiness, but results are subtle and not instant.
Irritation
low
Source
synthetic
Tetrapeptide-51 is a lab-made peptide that may help firm and smooth skin by supporting collagen, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-52 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Tetrapeptide-53 is a lab-made peptide that may help support collagen and firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Tetrapeptide-54 is a synthetic peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic