Ingredient review
Shikimoyl Hexapeptide-48
INCI: Shikimoyl Hexapeptide-48
A lab-made peptide that aims to mimic the skin-firming effects of shikimic acid, but clinical data is still limited.
In plain English
This ingredient is a synthetic peptide — a short chain of amino acids — that has been chemically linked to shikimic acid, a plant-derived compound. In skincare, it is used to help support the skin's natural structure, potentially making it look firmer and reducing the appearance of fine lines. Think of it as a signal molecule that tells skin cells to behave more youthfully, though the research is still early.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is still emerging, so marketing claims deserve extra caution.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- semi synthetic
- Evidence
- emerging
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Shikimoyl Hexapeptide-48 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Shikimoyl Hexapeptide-48.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
Shikimoyl Hexapeptide-48 is a semi-synthetic ingredient created by attaching shikimic acid (found in star anise and other plants) to a specific sequence of six amino acids (a hexapeptide). This combination is designed to enhance the peptide's ability to interact with skin cells.
How it works
The peptide portion is believed to bind to receptors on skin cells and stimulate the production of collagen and other structural proteins. Shikimic acid may add antioxidant-like properties and help calm inflammation, though the exact mechanism in skin is not fully proven. Together, they aim to support the skin's matrix for a firmer, smoother appearance.
Pros
Gentle on skin
Low irritation and comedogenic risk makes it suitable for most skin types, including sensitive skin.
Novel approach
Combines a plant-derived acid with a peptide for potential dual action — firming and soothing.
Cons and cautions
Limited evidence
Most data comes from lab or manufacturer studies, not large independent human trials, so results may vary.
Premium price
As a newer, specialty ingredient, products containing it tend to cost more than those with well-studied peptides.
Best for
- Adults looking for anti-aging support in their routine
- People with sensitive skin who want a gentle firming ingredient
Use caution if
- Those allergic to any peptide or shikimic acid derivative
- Anyone expecting immediate dramatic results — this is a gradual ingredient
Usage tips
Safety summary
Shikimoyl Hexapeptide-48 is considered safe for cosmetic use at typical concentrations. It has low irritation and comedogenic potential, and no significant safety concerns have been reported in available literature.
Research notes
Research on this specific peptide is limited to manufacturer-sponsored studies and early-stage investigations. While the concept is promising, independent peer-reviewed human trials are lacking, so efficacy claims should be viewed with caution.
Common label clues
- Typical concentration
- Typically 0.1% to 2% in leave-on products
- Regulatory status
- Approved as a cosmetic ingredient in major markets including the US, EU, and Asia. Not a drug or medical treatment.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- Produced synthetically, which reduces reliance on plant harvesting for shikimic acid. Manufacturing impact depends on the specific supplier.
Good to know
- Often found in serums or treatments labeled 'firming' or 'anti-aging'.
- Can be paired with other peptides or antioxidants like vitamin C for complementary benefits.
Common questions
What is Shikimoyl Hexapeptide-48 in beauty products?
This ingredient is a synthetic peptide — a short chain of amino acids — that has been chemically linked to shikimic acid, a plant-derived compound. In skincare, it is used to help support the skin's natural structure, potentially making it look firmer and reducing the appearance of fine lines. Think of it as a signal molecule that tells skin cells to behave more youthfully, though the research is still early.
What does Shikimoyl Hexapeptide-48 do in a beauty product?
The peptide portion is believed to bind to receptors on skin cells and stimulate the production of collagen and other structural proteins. Shikimic acid may add antioxidant-like properties and help calm inflammation, though the exact mechanism in skin is not fully proven. Together, they aim to support the skin's matrix for a firmer, smoother appearance.
Is Shikimoyl Hexapeptide-48 safe for most people?
Shikimoyl Hexapeptide-48 is considered safe for cosmetic use at typical concentrations. It has low irritation and comedogenic potential, and no significant safety concerns have been reported in available literature.
Who should be careful with Shikimoyl Hexapeptide-48?
Those allergic to any peptide or shikimic acid derivative Anyone expecting immediate dramatic results — this is a gradual ingredient
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.