Hexapeptide-32 is a lab-made peptide that may help soften expression lines and improve skin firmness, with a good safety profile for most skin types.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Hexapeptide-32 is a lab-made peptide that may help soften expression lines and improve skin firmness, with a good safety profile for most skin types.
Irritation
low
Source
synthetic
Hexapeptide-33 is a gentle synthetic peptide that may help support skin firmness and resilience, but research is still early.
Irritation
low
Source
synthetic
Hexapeptide-36 is a synthetic peptide that may help soften expression lines by temporarily relaxing facial muscles, similar to how a gentle muscle relaxant works.
Irritation
low
Source
synthetic
Hexapeptide-40 is a synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still limited compared to more established peptides.
Irritation
low
Source
synthetic
Hexapeptide-44 is a synthetic peptide that may help support skin firmness and reduce the appearance of fine lines, but research is still limited.
Irritation
low
Source
synthetic
A synthetic peptide that temporarily softens expression lines by calming muscle contractions, similar to a milder version of Argireline.
Irritation
low
Source
synthetic
Hexapeptide-47 is a synthetic peptide that may help calm skin and strengthen the moisture barrier, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften expression lines and improve skin firmness with consistent use.
Irritation
low
Source
synthetic
Hexapeptide-52 is a synthetic peptide that may help soften expression lines and improve skin firmness, but human data is still limited.
Irritation
low
Source
synthetic
Hexapeptide-53 is a lab-made peptide that may help support skin firmness and smooth fine lines, but research is still early.
Irritation
low
Source
synthetic
A peptide duo that may help smooth wrinkles and improve skin firmness, but results vary and more human studies are needed.
Irritation
low
Source
synthetic
Hexapeptide-57 is a synthetic peptide that may help soften expression lines and improve skin firmness, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Hexapeptide-58 is a lab-made peptide that may help soften expression lines and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften expression lines and improve skin firmness, but human data is still limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help smooth fine lines and improve skin firmness, but human data is still limited.
Irritation
low
Source
synthetic
Hexapeptide-63 is a synthetic peptide that may help support the look of firmer, smoother skin, but research is still emerging.
Irritation
low
Source
synthetic
Hexapeptide-64 is a synthetic peptide that may help reduce the appearance of fine lines by supporting the skin's natural repair processes.
Irritation
low
Source
synthetic
Hexapeptide-66 is a lab-made peptide that may help soften expression lines and support firmer-looking skin over time.
Irritation
low
Source
synthetic
A lab-made peptide that may help improve skin firmness and smooth fine lines, but human studies are still limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help soften expression wrinkles and improve skin firmness with minimal irritation risk.
Irritation
low
Source
synthetic
A lab-made peptide that aims to brighten skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that aims to brighten skin and reduce fine lines by combining a kojic acid-like signal with a collagen-supporting peptide.
Irritation
low
Source
synthetic
A synthetic peptide designed to support skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A peptide that helps reduce under-eye puffiness by encouraging fluid drainage, but results are subtle and not permanent.
Irritation
low
Source
synthetic
A gentle peptide that may help firm skin and calm irritation, but human research is still limited.
Irritation
low
Source
synthetic
Anti-aging agent
SR-(Tripeptide-68, Mussel Polypeptide-1, Mussel Oligopeptide-1, Mussel Polypeptide-1, Dipeptide-40)
A marine-inspired peptide blend that may help plump and firm skin, but research is still emerging.
Irritation
low
Source
semi-synthetic
Melittin is a bee venom peptide with promising lab research, but it's a strong irritant and not well-studied in cosmetic use—caution is advised.
Irritation
high
Source
natural
Anti-Aging Agent
S-METHANOCALDOCOCCUS JANNASCHII HEPTAPEPTIDE-1
A biotech peptide inspired by deep-sea microbes that may help support skin firmness and reduce signs of aging, though human research is still limited.
Irritation
low
Source
biotech
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-1 SR-JELLYFISH POLYPEPTIDE-1
A novel peptide blend that may support skin firmness and hydration, but human research is very limited.
Irritation
low
Source
semi-synthetic
A synthetic peptide that may help support skin firmness and repair, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help firm skin and soften fine lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-31 DECAPEPTIDE-40)
A synthetic peptide blend that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-59 DECAPEPTIDE-40
A lab-made peptide blend that may help signal skin to look firmer and smoother, but long-term human data is still limited.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-8 DECAPEPTIDE-40)
A synthetic peptide blend that may help firm skin and soften lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but human data is still limited.
Irritation
low
Source
synthetic
Skin conditioning agent
METHIONYL SH-POLYPEPTIDE-9 DECAPEPTIDE-40
A lab-made peptide that may help firm skin and soften lines, but human studies are limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help smooth wrinkles and firm skin, but research is still early and it's not a replacement for proven anti-aging ingredients.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften expression lines and improve skin firmness with low irritation risk.
Irritation
low
Source
synthetic
Anti-aging agent
METHYLENEDIOXYPHENYLSUCCINOYL HEPTAPEPTIDE-16
A synthetic peptide that may help soften expression lines and support firmer-looking skin, but research is limited to lab and small human studies.
Irritation
low
Source
synthetic
A lab-made peptide that may help tighten loose skin by signaling collagen support, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that mimics a natural skin signal to help support collagen and improve firmness, but research is still emerging.
Irritation
low
Source
synthetic
Miradenafil is a little-known synthetic compound with very limited published research; its cosmetic benefits and safety profile remain uncertain.
Irritation
moderate
Source
synthetic
A synthetic peptide with limited human research; its benefits are largely theoretical and based on animal studies.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed to confirm its effectiveness.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce fine lines and improve skin firmness by signaling collagen production.
Irritation
low
Source
synthetic
A well-studied peptide that may help soften fine lines by signaling skin to produce more collagen, but results are gradual and subtle.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften the look of expression lines and improve skin firmness with consistent use.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
A lab-made peptide that signals skin to produce more collagen, helping smooth fine lines over time.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce sagging, but more independent human studies are needed.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A well-studied peptide that may help reduce fine lines and improve skin firmness with consistent use, though results are gradual.
Irritation
low
Source
synthetic
A gentle peptide that may help smooth fine lines and calm skin irritation over time.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften expression lines and improve skin firmness with consistent use.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften fine lines, but results vary and it works best in a consistent routine.
Irritation
low
Source
synthetic