A synthetic peptide that may help reduce fine lines and improve skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A synthetic peptide that may help reduce fine lines and improve skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Heptapeptide-7 is a synthetic peptide that signals skin to produce more collagen, helping soften fine lines over time with minimal irritation.
Irritation
low
Source
synthetic
A synthetic peptide that signals skin to produce more collagen, helping soften fine lines over time.
Irritation
low
Source
synthetic
Heptapeptide-9 is a synthetic peptide that may help firm skin and soften fine lines by signaling collagen production, with low irritation risk.
Irritation
low
Source
synthetic
Skin conditioning agent
HEPTASODIUM HEXACARBOXYMETHYL DIPEPTIDE-12
A synthetic peptide that may help reduce fine lines and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Hexapeptide-1 is a synthetic peptide that may help soften expression lines by temporarily relaxing facial muscles, similar to a milder, topical version of neuromodulators.
Irritation
low
Source
synthetic
Hexapeptide-11 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Hexapeptide-34 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften fine lines and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
Hexapeptide-48 is a synthetic peptide that may help support skin firmness and reduce fine lines, but human research is still limited.
Irritation
low
Source
synthetic
Hexapeptide-49 is a lab-made peptide that may help improve skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Hexapeptide-50 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Hexapeptide-51 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
A synthetic peptide designed to support collagen and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
Hexapeptide-56 is a lab-made peptide that may help support skin firmness and reduce fine lines, but research is still early and it's less studied than more common peptides.
Irritation
low
Source
synthetic
Hexapeptide-61 is a synthetic peptide that may help support skin firmness and reduce the look of fine lines, though research is still emerging.
Irritation
low
Source
synthetic
Hexapeptide-62 is a synthetic peptide that may help soften expression lines by temporarily relaxing facial muscles, similar to other peptide ingredients.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but human studies are still limited.
Irritation
low
Source
synthetic
Hexapeptide-65 is a synthetic peptide that may help soften expression lines and improve skin firmness, but human data is still limited.
Irritation
low
Source
synthetic
A synthetic peptide designed to support collagen and reduce fine lines, generally well-tolerated but with limited independent research.
Irritation
low
Source
semi-synthetic
Anti-aging agent
HISTIDYL D-TRYPTOPHANYL DIPEPTIDE-29 D-PHENYLALANYL LYSINAMIDE
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more independent research is needed.
Irritation
low
Source
synthetic
A gentler, stabilized form of retinol that aims to reduce wrinkles and improve skin texture with less irritation than traditional retinol.
Irritation
low
Source
semi-synthetic
A novel, protein-rich ingredient with promising anti-aging potential, but human studies are limited and ethical sourcing is a concern.
Irritation
low
Source
natural
Film Former
Hydrolyzed Collagen PG-Propyl Methylsilanediol
A collagen-silicon hybrid that may help improve skin firmness and hydration, but results are subtle and not a replacement for medical treatments.
Irritation
low
Source
semi-synthetic
A gentle plant protein that may help improve skin firmness and reduce fine lines, but research is still early.
Irritation
low
Source
natural
A protein ingredient that may help support skin structure, but research is limited and benefits are not well-proven in humans.
Irritation
low
Source
natural
A gentle, plant-based alternative to animal-derived placental extracts, offering antioxidant and skin-conditioning benefits with limited but promising research.
Irritation
low
Source
natural
Hydrolyzed Thymus Extract is a protein-rich ingredient that may support skin firmness and repair, but evidence is limited and it may not be suitable for vegans or those with animal product sensitivities.
Irritation
low
Source
natural
A next-generation retinoid that aims to reduce fine lines and wrinkles with a gentler touch than traditional retinol.
Irritation
moderate
Source
semi-synthetic
Anti-wrinkle agent
Hydroxyethyl Isobutyl Piperidine Carboxylate
A synthetic ingredient that works like a gentle topical alternative to injectables for softening expression lines, but results are subtle and temporary.
Irritation
low
Source
synthetic
A synthetic peptide-like ingredient that may help soften expression lines, but research is still limited compared to well-studied peptides.
Irritation
low
Source
synthetic
A gentle yet effective retinoid that works like retinoic acid without the typical redness and peeling.
Irritation
low
Source
semi-synthetic
A synthetic amino acid derivative that may help improve skin firmness and reduce fine lines, but more human studies are needed.
Irritation
low
Source
synthetic
A gentle amino acid derivative that may help boost collagen and improve skin firmness, though research is still emerging.
Irritation
low
Source
semi-synthetic
A synthetic compound that may help firm skin and reduce wrinkles, but clinical evidence is still limited.
Irritation
low
Source
synthetic
A synthetic peptide-like ingredient that helps soften expression lines by temporarily relaxing facial muscles, offering a gentler alternative to injectables.
Irritation
low
Source
synthetic
A marine peptide blend that may help firm and repair skin, but research is still early and benefits are not guaranteed.
Irritation
low
Source
mixed
A marine-inspired peptide that may help hydrate and firm skin, but human research is still limited.
Irritation
low
Source
biotech
Kephalis is a synthetic peptide that may help smooth wrinkles and support skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
Kinetin is a gentle plant-derived ingredient that may help improve skin texture and reduce fine lines without the irritation of stronger anti-aging actives.
Irritation
low
Source
natural
A silicone-modified elastin derivative that may temporarily improve skin firmness and hydration, but long-term anti-aging benefits are not well proven.
Irritation
low
Source
semi-synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is limited to lab and small-scale studies.
Irritation
low
Source
synthetic
A synthetic peptide blend that may help firm skin and soften fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-75 SH-POLYPEPTIDE-8
A lab-made peptide duo that may help smooth wrinkles and improve skin firmness, but results vary and more human studies are needed.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-OLIGOPEPTIDE-2 DECAPEPTIDE-40
A synthetic peptide blend that may help support collagen and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40
A synthetic peptide blend that may help support skin firmness and reduce fine lines, but human research is still limited.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-13 DECAPEPTIDE-40
A synthetic peptide blend that may help firm skin and soften lines, but human research is still limited.
Irritation
low
Source
synthetic
Anti-Aging Agent
METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40
A lab-made peptide blend that may help firm skin and soften lines, but human research is still limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and smooth fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
Anti-aging agent
R-(METHIONYL SH-POLYPEPTIDE-60 DECAPEPTIDE-40)
A synthetic peptide blend that may help firm skin and soften wrinkles, but research is still early.
Irritation
low
Source
synthetic
Anti-aging agent
METHIONYL SH-POLYPEPTIDE-76 DECAPEPTIDE-40
A synthetic peptide complex that may help signal skin to appear firmer and smoother, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help signal skin to look firmer and smoother, but human studies are limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and firm skin, but human studies are still limited.
Irritation
low
Source
synthetic
Skin-conditioning agent
METHIONYL SH-POLYPEPTIDE-7 ALANYL SR-SPIDER OLIGOPEPTIDE-1
A lab-made peptide blend that mimics spider silk to help skin feel firmer, but research is still early and benefits are not guaranteed.
Irritation
low
Source
synthetic
A gentle, PEG-modified retinoid that may support smoother skin with less irritation than traditional retinol, but research is still emerging.
Irritation
low
Source
semi-synthetic