An experimental, cholesterol-linked RNA ingredient with potential for targeted skin delivery, but lacks broad safety and efficacy data for cosmetic use.
Irritation
moderate
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
An experimental, cholesterol-linked RNA ingredient with potential for targeted skin delivery, but lacks broad safety and efficacy data for cosmetic use.
Irritation
moderate
Source
synthetic
Phytoglobin is a plant-based protein that may help boost skin oxygenation and radiance, but research is still emerging and it's not a proven substitute for clinical treatments.
Irritation
low
Source
biotech
A gentler, fermented form of retinol that may support smoother, brighter skin with less irritation than traditional retinol.
Irritation
low
Source
biotech
Piperine may boost ingredient absorption but can be irritating; it's not a common or well-studied skincare ingredient on its own.
Irritation
moderate
Source
natural
Skin conditioning agent
Pig Dental Pulp Cell/Adipocyte/Bone Marrow Cell Conditioned Media
An experimental biotech ingredient from pig cells with limited human research and ethical concerns; not recommended for routine use.
Irritation
moderate
Source
biotech
A synthetic ingredient that may help slow hair thinning by reducing collagen buildup around hair follicles, but results vary and it works best as part of a comprehensive hair care routine.
Irritation
low
Source
synthetic
Skin conditioning
RED JUNGLEFOWL BLASTODERM PLURIPOTENT CELL CULTURE CONDITIONED MEDIA
A novel biotech ingredient from bird stem cells that may support skin repair, but human research is very limited.
Irritation
low
Source
biotech
Retinol is a gold-standard anti-aging ingredient that speeds up skin renewal but can cause irritation if not introduced gradually.
Irritation
moderate
Source
semi-synthetic
A retinol-peptide hybrid that aims to smooth fine lines and improve texture with a gentler touch than plain retinol.
Irritation
moderate
Source
semi-synthetic
A next-generation retinoid that aims to smooth wrinkles and improve skin texture with a gentler touch than standard retinol.
Irritation
low
Source
semi-synthetic
A gentle, water-soluble retinoid that offers anti-aging benefits with less irritation than traditional retinol.
Irritation
low
Source
semi-synthetic
A synthetic peptide that may help reduce fine lines by signaling skin to produce more collagen, but human data is still limited.
Irritation
low
Source
synthetic
SH-Polypeptide-45 is a lab-made peptide that may help support firmer-looking skin, but research is still early and results vary.
Irritation
low
Source
synthetic
SH-Polypeptide-69 is a lab-made peptide that may help signal skin to produce more collagen, but research is still early and results vary.
Irritation
low
Source
synthetic
A lab-made peptide that may help support collagen and improve skin firmness, but research is still early and results vary.
Irritation
low
Source
synthetic
Conditioning Agent
SHEEP ADIPOSE STROMAL CELL CONDITIONED MEDIA
An exotic, high-tech ingredient with limited human research; may offer anti-aging benefits but raises ethical and safety questions.
Irritation
moderate
Source
biotech
A novel biotech ingredient that may support skin repair, but human evidence is still limited.
Irritation
low
Source
biotech
A next-generation retinoid designed to deliver anti-aging benefits with less irritation than traditional retinol.
Irritation
low
Source
semi-synthetic
A lab-made compound that may help improve skin firmness and smoothness, but research is still early and limited.
Irritation
low
Source
synthetic
Skin conditioning agent
Immortalized Human Tooth Pulp Stem Cell Conditioned Media
A novel biotech ingredient with promising lab research but very limited human studies; best viewed as a luxury novelty rather than a proven essential.
Irritation
low
Source
biotech
Synephrine may offer temporary skin firming effects, but evidence is limited and it can cause irritation, especially at higher concentrations.
Irritation
moderate
Source
natural
Synephrine HCL is a synthetic ingredient sometimes added to cosmetics for a temporary tightening sensation, but its effectiveness and safety for topical use are not well-established.
Irritation
moderate
Source
synthetic
Anti-wrinkle agent
T-BUTYLCHROMENAMIDO FLUOROBENZYL METHANESULFONAMIDE
A synthetic peptide-like ingredient that may help soften expression lines, but research is still emerging and it's not a replacement for proven treatments.
Irritation
low
Source
synthetic
Tazarotene is a potent prescription retinoid that effectively treats acne and reduces fine lines, but it requires careful use due to high irritation potential.
Irritation
high
Source
synthetic
A synthetic ingredient that may help reduce hair shedding and support thicker-looking hair, but evidence is still building.
Irritation
low
Source
synthetic
A synthetic compound that may help soften expression lines by relaxing facial muscles, but research is still limited compared to more established ingredients.
Irritation
low
Source
synthetic
Theophylline may temporarily tighten skin and improve circulation, but results are modest and it can cause irritation for sensitive skin.
Irritation
moderate
Source
synthetic
Thymidine is a gentle, science-backed ingredient that helps support skin’s natural repair processes, making it a smart addition to anti-aging and recovery routines.
Irritation
low
Source
biotech
Conditioning Agent
Human Tooth Pulp Stem Cell Conditioned Media
An exotic, high-tech ingredient with very limited human research; its benefits are largely theoretical and not proven in everyday skincare.
Irritation
low
Source
biotech
A powerful prescription retinoid that effectively treats acne and reduces signs of aging, but requires careful use due to high irritation potential.
Irritation
high
Source
synthetic
A gentle, next-generation retinoid alternative that pairs vitamin A activity with skin-identical lipid support, but clinical evidence is still limited.
Irritation
low
Source
semi-synthetic
Trisodium Chlorin E6 is a light-activated compound used in professional treatments, not a daily skincare ingredient.
Irritation
moderate
Source
semi-synthetic
An exotic, animal-derived ingredient with potential skin-repair benefits but limited human research and ethical concerns.
Irritation
moderate
Source
natural
A gentler retinoid that aims to give you the anti-aging perks of retinoic acid with less redness and peeling.
Irritation
low
Source
semi-synthetic