Ingredient review
SH-Polypeptide-106
INCI: SH-Polypeptide-106
A synthetic peptide that may help reduce fine lines by signaling skin to produce more collagen, but human data is still limited.
In plain English
SH-Polypeptide-106 is a lab-made chain of amino acids (a peptide) that acts like a messenger to your skin cells. When applied in a cream or serum, it tells your skin to make more collagen and elastin, which are the proteins that keep skin plump and firm. Think of it as a gentle nudge to your skin's natural repair system, not a magic eraser.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
SH-Polypeptide-106 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging SH-Polypeptide-106.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
SH-Polypeptide-106 is a synthetic peptide, meaning it is a short chain of amino acids created in a laboratory. It belongs to a class of ingredients called signal peptides, which are designed to mimic natural peptides that trigger collagen production in the skin.
How it works
When applied topically, SH-Polypeptide-106 penetrates the outer layer of the skin and binds to receptors on fibroblasts (the cells that make collagen). This binding sends a signal to the cell to ramp up production of collagen and other structural proteins, which can help improve skin firmness and reduce the appearance of fine lines over time.
Pros
Gentle anti-aging support
SH-Polypeptide-106 is unlikely to cause irritation or peeling, making it a good option for sensitive skin types who want to support collagen production without redness.
Compatible with many routines
It can be layered with other active ingredients like vitamin C, niacinamide, and hyaluronic acid without causing negative reactions, so it fits easily into most skincare regimens.
Cons and cautions
Subtle, slow results
Unlike retinoids, which can produce visible changes in weeks, SH-Polypeptide-106 works gradually over months. Users expecting quick improvement may be disappointed.
Limited independent research
Most evidence comes from manufacturer studies or ingredient suppliers. There are fewer peer-reviewed human trials compared to more established peptides, so the claims should be taken with caution.
Best for
- Adults looking for a gentle anti-aging ingredient to support collagen over time
- People with sensitive skin who cannot tolerate stronger actives like retinoids
Use caution if
- Those seeking immediate or dramatic wrinkle reduction
Usage tips
Safety summary
SH-Polypeptide-106 is considered safe for topical cosmetic use at typical concentrations. It has a low irritation and comedogenic risk, and no significant safety concerns have been reported in available data.
Research notes
Evidence for SH-Polypeptide-106 is primarily based on in vitro studies and manufacturer-sponsored research. While signal peptides in general have moderate support for collagen stimulation, specific human clinical data for this exact peptide is limited.
Common label clues
- Typical concentration
- Typically used at 0.1% to 1% in leave-on products
- Regulatory status
- Approved for cosmetic use in the US, EU, and other major markets. It is not classified as a drug ingredient.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- As a synthetic peptide, its production is lab-based and does not rely on animal or plant harvesting, which may be a plus for sustainability-conscious consumers.
Good to know
- Peptides are generally more stable in anhydrous (water-free) or well-preserved formulas.
- SH-Polypeptide-106 is often combined with other peptides in a single product for a broader anti-aging effect.
Common questions
What is SH-Polypeptide-106 in beauty products?
SH-Polypeptide-106 is a lab-made chain of amino acids (a peptide) that acts like a messenger to your skin cells. When applied in a cream or serum, it tells your skin to make more collagen and elastin, which are the proteins that keep skin plump and firm. Think of it as a gentle nudge to your skin's natural repair system, not a magic eraser.
What does SH-Polypeptide-106 do in a beauty product?
When applied topically, SH-Polypeptide-106 penetrates the outer layer of the skin and binds to receptors on fibroblasts (the cells that make collagen). This binding sends a signal to the cell to ramp up production of collagen and other structural proteins, which can help improve skin firmness and reduce the appearance of fine lines over time.
Is SH-Polypeptide-106 safe for most people?
SH-Polypeptide-106 is considered safe for topical cosmetic use at typical concentrations. It has a low irritation and comedogenic risk, and no significant safety concerns have been reported in available data.
Who should be careful with SH-Polypeptide-106?
Those seeking immediate or dramatic wrinkle reduction
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.