Tripeptide-66 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Tripeptide-66 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
Tripeptide-67 is a lab-made peptide that may help firm skin and soften fine lines, though research is still early compared to more established peptides.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce fine lines, but research is still early and results vary.
Irritation
low
Source
synthetic
A peptide duo that may help soften expression lines and improve skin firmness with minimal irritation risk.
Irritation
low
Source
synthetic
A peptide duo that may help improve skin firmness and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with a good safety profile for most skin types.
Irritation
low
Source
synthetic
A silicone that gives a silky, smooth feel to products without clogging pores or causing irritation.
Irritation
low
Source
synthetic
Triphenyl phosphate is a synthetic plasticizer used in nail products, but it has raised some health concerns due to potential endocrine disruption and skin irritation.
Irritation
moderate
Source
synthetic
A lightweight silicone that smooths skin and hair without feeling heavy or greasy.
Irritation
low
Source
synthetic
Antioxidant
Coix Lacryma-Jobi Ma-Yuen Seed/Pueraria Lobata Root/Ganoderma Lucidum Extract
A gentle botanical trio that may help calm skin and fight free radicals, but research is still early.
Irritation
low
Source
natural
Antioxidant
Poncirus Trifoliata Fruit/Houttyunia Cordata/Hemerocallis Fulva Root Extract
A gentle botanical blend that may help calm skin and fight free radicals, but research is limited.
Irritation
low
Source
natural
Soothing Agent
ARTEMISIA DRACUNCULUS SEED/ANTHEMIS NOBILIS SEED/HYPERICUM ANDROSAEMUM SEED EXTRACT
A gentle botanical blend that may calm skin and fight free radicals, but research is limited and benefits are not guaranteed.
Irritation
low
Source
natural
A gentle, licorice-derived ingredient that helps calm redness and irritation without clogging pores.
Irritation
low
Source
natural
A plant-derived compound modified for stability that may help firm skin and reduce fine lines, but human studies are limited.
Irritation
low
Source
semi-synthetic
A gentle, synthetic emollient and solvent that helps products spread smoothly and prevents nail polish from becoming brittle.
Irritation
low
Source
synthetic
This is an industrial adhesive ingredient, not a skincare active; it may cause skin irritation and is best avoided in leave-on products.
Irritation
high
Source
synthetic
A plant-based extract with early research suggesting anti-inflammatory benefits, but limited human studies and potential for irritation.
Irritation
moderate
Source
natural
Triricinolein is a gentle, castor-oil-derived emollient that softens skin and helps lock in moisture without clogging pores.
Irritation
low
Source
natural
Tris Buffered Saline is a gentle pH buffer that helps keep skincare products stable and comfortable on sensitive skin.
Irritation
low
Source
synthetic
A synthetic stabilizer that helps keep formulas consistent, but is rarely the star ingredient.
Irritation
low
Source
synthetic
A stable synthetic antioxidant that helps prevent oils and other ingredients from going rancid, but it's not a star active for skin benefits.
Irritation
low
Source
synthetic
A highly effective, photostable UV filter that provides broad-spectrum protection with minimal irritation risk.
Irritation
low
Source
synthetic
A gentle synthetic dispersant that helps pigments and sunscreen actives spread evenly without irritation.
Irritation
low
Source
synthetic
A synthetic film-former that helps makeup last longer and resist water, but may feel stiff on skin.
Irritation
low
Source
synthetic
A synthetic film-former used in nail products to create strong, flexible coatings, but may cause skin irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
An effective preservative booster that helps keep products fresh, but may cause irritation for sensitive skin at higher concentrations.
Irritation
moderate
Source
synthetic
A mild synthetic surfactant that helps cleansers foam and rinse cleanly without stripping the skin.
Irritation
low
Source
synthetic
A synthetic silicone that helps products resist water and sweat, but may feel heavy on some skin types.
Irritation
low
Source
synthetic
A gentle synthetic preservative booster that helps keep your products fresh without the harshness of traditional preservatives.
Irritation
low
Source
synthetic
An effective preservative that works by releasing tiny amounts of formaldehyde, making it a controversial choice for sensitive skin.
Irritation
moderate
Source
synthetic
An effective synthetic antioxidant for preserving formulas, but its environmental and health profile raises caution.
Irritation
low
Source
synthetic
A gentle synthetic emollient that softens skin and improves product texture without clogging pores.
Irritation
low
Source
synthetic
A synthetic antioxidant that helps neutralize free radicals and stabilize formulas, but research on its skin benefits is still emerging.
Irritation
low
Source
synthetic
A silicone film former that helps products spread smoothly and resist water, but offers no active skincare benefits.
Irritation
low
Source
synthetic
A fast-evaporating silicone that gives a smooth, silky feel without heavy residue — great for lightweight formulas.
Irritation
low
Source
synthetic
A silicone-based film former that helps makeup and skincare last longer and feel smooth, with a low risk of irritation.
Irritation
low
Source
synthetic
A gentle peptide complex that may help calm redness and strengthen the skin barrier, but research is still early.
Irritation
low
Source
biotech
A gentle, stable vitamin C derivative that brightens skin and fights free radicals without the sting of pure ascorbic acid.
Irritation
low
Source
semi-synthetic
A gentle, stable vitamin C derivative that brightens skin and fights free radicals without the sting of pure ascorbic acid.
Irritation
low
Source
semi-synthetic
Trisodium Chlorin E6 is a light-activated compound used in professional treatments, not a daily skincare ingredient.
Irritation
moderate
Source
semi-synthetic
A modern, eco-friendly alternative to EDTA that helps your products stay effective and stable without irritation.
Irritation
low
Source
synthetic
A safe and effective stabilizer that helps your products stay fresh and work better by neutralizing unwanted metals.
Irritation
low
Source
synthetic
A gentle, biodegradable alternative to traditional chelating agents that protects your skincare formulas from metal-induced degradation.
Irritation
low
Source
synthetic
A gentle, sugar-based humectant that hydrates skin and may help energize skin cells for a healthier appearance.
Irritation
low
Source
semi-synthetic
A gentle, licorice-derived salt that calms redness and irritation without the side effects of pure licorice extract.
Irritation
low
Source
natural
A gentle chelating agent that protects your skincare formulas from metal contamination, helping them stay effective longer.
Irritation
low
Source
synthetic
A gentle chelating agent that helps protect your products from mineral-related instability and may offer mild antioxidant benefits for skin.
Irritation
low
Source
natural
Surfactant
TRISODIUM LAUROAMPHO PG-ACETATE CHLORIDE PHOSPHATE
A gentle, low-irritation surfactant that effectively cleanses without stripping the skin, making it a good choice for sensitive or dry skin types.
Irritation
low
Source
synthetic
Trisodium phosphate is a synthetic pH adjuster that helps keep products stable, but it can be drying or irritating in high concentrations.
Irritation
moderate
Source
synthetic
A stabilized, water-friendly version of resveratrol that offers antioxidant protection without the stability issues of the original compound.
Irritation
low
Source
semi-synthetic
A gentle, synthetic surfactant that effectively cleanses without the harshness of traditional sulfates, making it a good option for sensitive skin.
Irritation
low
Source
synthetic
Skin conditioning agent
TRISODIUM TETRAMETHYLHEXADECENYLCYSTEINE BIS-CARBOXYMETHYL FORMYLAMINE
A novel synthetic amino-acid derivative that may help improve skin feel and hydration, but independent research is limited.
Irritation
low
Source
synthetic
A gentle, antioxidant-rich plant extract that may help calm skin and defend against environmental stress, though research is still early.
Irritation
low
Source
natural
Antistatic Agent
Tristeardimonium Acetyl Castor Oil Chloride
A gentle conditioning ingredient that reduces static and softens hair without heavy buildup.
Irritation
low
Source
semi-synthetic
Tristearin is a gentle, plant-derived emollient that softens skin and gives creams a smooth, luxurious feel without clogging pores.
Irritation
low
Source
natural
A gentle, plant-derived emollient that softens skin and improves product feel without common irritation or clogging concerns.
Irritation
low
Source
natural
A synthetic emulsifier that helps blend oil and water in creams and lotions, generally considered safe and non-irritating.
Irritation
low
Source
synthetic
A gentle botanical extract with potential soothing and antioxidant benefits, though research is limited.
Irritation
low
Source
natural
A gentle botanical extract with antioxidant potential, but research is limited and benefits are not well-established.
Irritation
low
Source
natural