A lab-grown version of the popular centella asiatica (cica) that delivers soothing and skin-repairing benefits with high purity and consistency.
Irritation
low
Source
biotech
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A lab-grown version of the popular centella asiatica (cica) that delivers soothing and skin-repairing benefits with high purity and consistency.
Irritation
low
Source
biotech
A gentle, antioxidant-rich extract from the centella plant that helps calm irritation and supports the skin's natural repair process.
Irritation
low
Source
natural
A well-researched botanical that calms redness, supports collagen, and strengthens the skin barrier with minimal irritation risk.
Irritation
low
Source
natural
Soothing Agent
CENTELLA ASIATICA LEAF CELL CULTURE EXTRACT
A gentle, lab-grown version of the classic soothing herb Centella asiatica, offering antioxidant and calming benefits with minimal irritation risk.
Irritation
low
Source
biotech
A gentle, lab-grown version of Centella asiatica that helps calm irritation and protect skin from environmental stress.
Irritation
low
Source
biotech
A gentle, hydrating base ingredient that soothes irritation and supports skin barrier health, ideal for sensitive or reactive skin.
Irritation
low
Source
natural
A gentle, biotech-derived ingredient that harnesses the power of Centella asiatica stem cells to calm and protect the skin.
Irritation
low
Source
biotech
Soothing Agent
CENTELLA ASIATICA MERISTEM CELL CULTURE EXTRACT
A gentle, lab-grown version of the popular soothing herb, offering antioxidant and calming benefits with minimal irritation risk.
Irritation
low
Source
biotech
A gentle, plant-based powder that helps calm irritated skin and supports a healthy skin barrier, but its effectiveness depends on the specific active compounds present.
Irritation
low
Source
natural
A gentle, plant-based extract that helps calm redness and supports a healthy-looking skin barrier.
Irritation
low
Source
natural
A gentle botanical extract with antioxidant and soothing potential, but research is still early and product benefits may vary.
Irritation
low
Source
natural
A lab-made peptide inspired by centipede venom that may help relax facial muscles and reduce the look of fine lines, but research is still early.
Irritation
low
Source
synthetic
A novel synthetic peptide that may help firm and smooth skin, but research is still early and benefits are not yet proven in large human studies.
Irritation
low
Source
synthetic
A gentle, plant-based extract with potential soothing and antioxidant benefits, though research is still limited.
Irritation
low
Source
natural
Cera Alba is a gentle, natural wax that helps lock in moisture and gives products a smooth, protective texture.
Irritation
low
Source
natural
A skin-identical lipid that strengthens the moisture barrier and reduces water loss.
Irritation
low
Source
semi-synthetic
Ceramide 1 A is a skin-identical lipid that strengthens the moisture barrier, making it a gentle and effective choice for dry or sensitive skin.
Irritation
low
Source
semi-synthetic
Ceramide 2 is a skin-identical lipid that strengthens the moisture barrier, making it a gentle and effective choice for dry or sensitive skin.
Irritation
low
Source
semi-synthetic
Ceramide 4 is a skin-identical lipid that strengthens the moisture barrier and helps prevent dryness and irritation.
Irritation
low
Source
semi-synthetic
Ceramide 5 is a skin-identical lipid that strengthens the moisture barrier, making it a gentle and effective choice for dry or sensitive skin.
Irritation
low
Source
semi-synthetic
A skin-identical ceramide that strengthens the moisture barrier and reduces water loss, making it a staple for dry or sensitive skin.
Irritation
low
Source
synthetic
A potent ceramide that reinforces the skin barrier, reduces water loss, and soothes sensitivity.
Irritation
low
Source
semi-synthetic
Ceramide AP is a skin-identical lipid that helps repair the moisture barrier, making it a gentle and effective choice for dry or sensitive skin.
Irritation
low
Source
semi-synthetic
Ceramide EOP is a key skin lipid that strengthens the moisture barrier, making it ideal for dry or sensitive skin.
Irritation
low
Source
semi-synthetic
A skin-identical lipid that strengthens the moisture barrier and reduces water loss.
Irritation
low
Source
semi-synthetic
A synthetic ceramide that mimics skin's natural lipids to strengthen the moisture barrier and reduce water loss.
Irritation
low
Source
synthetic
A skin-identical lipid that strengthens the moisture barrier and reduces water loss.
Irritation
low
Source
semi-synthetic
A synthetic ceramide that helps strengthen the skin barrier and lock in moisture, with low irritation potential.
Irritation
low
Source
synthetic
A gentle, barrier-strengthening lipid that helps dry or sensitive skin retain moisture without irritation.
Irritation
low
Source
semi-synthetic
A synthetic ingredient that mimics ceramides to help strengthen the skin barrier and improve moisture retention.
Irritation
low
Source
synthetic
A gentle red algae extract that helps hydrate and calm the skin, but research on its specific benefits is still limited.
Irritation
low
Source
natural
A gentle marine extract that may help hydrate and calm the skin, but research is still early.
Irritation
low
Source
natural
A plant extract with promising antioxidant and soothing potential, but research is still early and benefits are not yet proven in human skincare studies.
Irritation
low
Source
natural
Cerebrosides are skin-identical lipids that help reinforce the skin barrier and lock in moisture, making them a gentle choice for dry or sensitive skin.
Irritation
low
Source
natural
Ceresin is a safe, non-irritating wax that gives products a smooth texture and helps lock in moisture.
Irritation
low
Source
synthetic
A gentle, plant-based humectant that helps hydrate and soothe the skin, with antioxidant benefits to protect against environmental stress.
Irritation
low
Source
natural
A gentle cactus extract that may help calm and hydrate the skin, but research is still early.
Irritation
low
Source
natural
A gentle, hydrating cactus fruit juice with antioxidant potential, best for dry or sensitive skin types.
Irritation
low
Source
natural
A mineral blend that improves powder texture and oil control, but may not suit very dry skin.
Irritation
low
Source
natural
A fermented mushroom filtrate that may help calm skin and fight oxidative stress, though human studies are still limited.
Irritation
low
Source
biotech
A mushroom-derived ingredient with antioxidant potential, but research is still early.
Irritation
low
Source
natural
A gentle, wax-derived fatty acid that helps soften and smooth skin while reinforcing the moisture barrier.
Irritation
low
Source
natural
A gentle silicone that smooths skin and reduces friction without clogging pores, making it a reliable texture enhancer for many formulas.
Irritation
low
Source
synthetic
A gentle botanical extract with traditional use but very limited modern cosmetic research; may offer soothing and antioxidant benefits but is not a proven powerhouse.
Irritation
low
Source
natural
Cetalkonium chloride is an effective preservative and conditioning agent, but it may cause irritation for sensitive skin or eyes.
Irritation
moderate
Source
synthetic
Cetealkonium bromide is an effective conditioning and antimicrobial ingredient, but it can be irritating for sensitive skin and is best used in rinse-off formulas.
Irritation
moderate
Source
synthetic
Hair Conditioning Agent
CETEARAMIDOETHYL DIETHONIUM HYDROLYZED WHEAT PROTEIN
A gentle, protein-derived conditioning agent that helps reduce frizz and static without heavy buildup.
Irritation
low
Source
semi-synthetic
Hair Conditioning Agent
CETEARAMIDOETHYL DIETHONIUM ISOSTEAROYL HYDROLYZED SILK
A gentle conditioning ingredient derived from silk that helps smooth hair and soften skin without heavy buildup.
Irritation
low
Source
semi-synthetic
Hair Conditioning Agent
CETEARAMIDOETHYLDIETHONIUM SUCCINOYL HYDROLYZED COLLAGEN
A modified collagen peptide that helps condition hair and skin by forming a lightweight, moisture-binding film.
Irritation
low
Source
semi-synthetic
Hair Conditioning Agent
CETEARAMIDOETHYLDIETHONIUM SUCCINOYL HYDROLYZED SILK
A gentle, silk-derived conditioning ingredient that adds softness and shine to hair and skin without heavy buildup.
Irritation
low
Source
semi-synthetic
Antistatic Agent
CETEARAMIDOPROPYL LAUROYLETHYLDIMONIUM METHOSULFATE
A gentle conditioning ingredient that helps detangle hair and reduce frizz without heavy buildup.
Irritation
low
Source
semi-synthetic
Ceteardimonium Chloride is a synthetic conditioning agent that reduces static and softens hair, but it may cause irritation or clog pores in sensitive individuals.
Irritation
moderate
Source
synthetic
Ceteareth-10 is a gentle emulsifier that helps create stable, creamy textures in skincare, but it may be slightly drying for very sensitive skin.
Irritation
low
Source
semi-synthetic
Ceteareth-10 Phosphate is a gentle emulsifier that helps mix oil and water in products, with low irritation potential and good skin compatibility.
Irritation
low
Source
semi-synthetic
Ceteareth-100 is a reliable emulsifier that helps blend oil and water in creams and lotions, but it is a PEG compound, which raises mild concerns about potential impurities.
Irritation
low
Source
semi-synthetic
Ceteareth-11 is a gentle emulsifier that helps create stable, creamy textures in skincare without common irritation.
Irritation
low
Source
semi-synthetic
Ceteareth-12 is a reliable emulsifier that helps products feel smooth, but it may cause irritation for sensitive skin due to its cleansing nature.
Irritation
moderate
Source
synthetic
A reliable emulsifier that keeps your lotions and creams smooth and stable, with a low risk of irritation.
Irritation
low
Source
synthetic
Ceteareth-14 is a reliable emulsifier that keeps creams smooth and stable, but it may be less gentle for very sensitive skin due to its surfactant nature.
Irritation
low
Source
synthetic
Ceteareth-15 is a safe, widely used emulsifier that helps create stable, creamy textures in skincare, though it may be slightly drying for very sensitive skin.
Irritation
low
Source
synthetic