Tioxolone is a synthetic exfoliant with antimicrobial properties, but research on its effectiveness and safety is limited compared to more common ingredients like salicylic acid.
Irritation
moderate
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Tioxolone is a synthetic exfoliant with antimicrobial properties, but research on its effectiveness and safety is limited compared to more common ingredients like salicylic acid.
Irritation
moderate
Source
synthetic
A gentle, amino-acid-based surfactant that cleans without stripping the skin barrier.
Irritation
low
Source
semi-synthetic
A mild surfactant alternative to SLS, but may still cause irritation for sensitive skin.
Irritation
moderate
Source
synthetic
TIPA Myristate helps blend oil and water in creams, but may clog pores for acne-prone skin.
Irritation
low
Source
synthetic
TIPA Stearate is a reliable emulsifier that helps create smooth, stable creams and lotions, but it may not suit those seeking entirely natural ingredients.
Irritation
low
Source
synthetic
A synthetic film-former that helps products stay put longer, but may feel tight or stiff on some skin types.
Irritation
low
Source
synthetic
A mild, semi-synthetic surfactant that helps create a rich lather while being gentle enough for sensitive skin.
Irritation
low
Source
semi-synthetic
A mild alternative to SLS/SLES, but still a surfactant that can be drying for sensitive skin.
Irritation
moderate
Source
synthetic
Film Former
ISOPROPYL TITANIUM TRIISOSTEARATE/TRIETHOXYCAPRYLYLSILANE CROSSPOLYMER
A synthetic crosspolymer that helps makeup last longer and feel smoother, with a low risk of irritation.
Irritation
low
Source
synthetic
Film Former
ISOPROPYL TITANIUM TRIISOSTEARATE/PERFLUOROOCTYL TRIETHOXYSILANE CROSSPOLYMER
A synthetic film former that helps makeup and sunscreen stay put longer, but it's not a skincare active.
Irritation
low
Source
synthetic
A well-studied mineral sunscreen ingredient that provides broad-spectrum UV protection with minimal irritation risk.
Irritation
low
Source
natural
Titanium hydroxide is a gentle mineral opacifier that helps give makeup a smooth, opaque finish, but it's less common than titanium dioxide and offers no UV protection on its own.
Irritation
low
Source
natural
Titanium Isostearates is a safe, synthetic binder that helps pressed powders and color cosmetics hold together without causing irritation.
Irritation
low
Source
synthetic
Titanium Nitride is a safe, non-irritating pigment that adds shimmer and color to makeup, but it offers no skincare benefits.
Irritation
low
Source
synthetic
Titanium Salicylate is a synthetic UV filter that helps protect skin from sun damage, but its use is less common than other filters and may require more research for long-term safety.
Irritation
low
Source
synthetic
Film Former
ISOPROPYL TITANIUM TRIISOSTEARATE/TRIETHOXYSILYLETHYL POLYDIMETHYLSILOXYETHYL DIMETHICONE CROSSPOLYMER
A specialized silicone-based ingredient that helps makeup and sunscreen stay put and feel silky, but it's not a skincare active.
Irritation
low
Source
semi-synthetic
A gentle plant extract with antioxidant potential, but research is still early and benefits are not yet proven in human skin.
Irritation
low
Source
natural
A plant extract with early research suggesting antioxidant benefits, but limited human studies for skincare.
Irritation
low
Source
natural
A gentle silicone that helps products spread smoothly and feel silky without clogging pores.
Irritation
low
Source
synthetic
Tobacco flower extract is a gentle antioxidant that may help calm skin, but research is still early and it's not a proven powerhouse.
Irritation
low
Source
natural
Tobacco flower oil adds a unique scent to products but has limited research on skin benefits and may irritate sensitive skin.
Irritation
moderate
Source
natural
A biotech antioxidant from tobacco leaf cells that helps protect skin from environmental stress and supports a more even tone.
Irritation
low
Source
biotech
Tobacco leaf extract is an antioxidant-rich botanical that may help soothe and protect skin, but research is still emerging and it's not a mainstream ingredient.
Irritation
low
Source
natural
Tobacco leaf oil is a controversial ingredient with potential antioxidant benefits but significant safety concerns, including skin irritation and nicotine content.
Irritation
high
Source
natural
A plant-derived peptide blend that may help firm skin and soften wrinkles, but research is still early.
Irritation
low
Source
biotech
A novel peptide complex from tobacco plants that may support collagen and skin firmness, but research is still early.
Irritation
low
Source
biotech
Tococysteamide is a gentle antioxidant that may help brighten skin and defend against pollution, but research is still early.
Irritation
low
Source
synthetic
A gentle, water-soluble vitamin E derivative that helps protect skin from environmental damage without the greasiness of pure vitamin E.
Irritation
low
Source
semi-synthetic
A water-soluble form of vitamin E that provides antioxidant protection and helps stabilize other ingredients, but may be less potent than pure tocopherol.
Irritation
low
Source
semi-synthetic
A gentle, water-soluble vitamin E derivative that helps protect skin from oxidative stress without the greasy feel of pure tocopherol.
Irritation
low
Source
semi-synthetic
A gentle, water-soluble vitamin E derivative that helps protect skin from environmental stress while adding light hydration.
Irritation
low
Source
semi-synthetic
A gentle, water-friendly version of vitamin E that helps protect skin from environmental damage without the greasy feel of regular vitamin E.
Irritation
low
Source
semi-synthetic
Tocopherol is a well-studied antioxidant that helps neutralize free radicals and supports skin barrier function, making it a gentle, beneficial addition to most routines.
Irritation
low
Source
natural
A gentle antioxidant blend that pairs vitamin E with wheat proteins to support skin barrier function and provide light hydration.
Irritation
low
Source
mixed
A gentle, water-soluble vitamin E derivative that helps protect skin from oxidative stress and improves product stability.
Irritation
low
Source
semi-synthetic
A stable, well-tolerated form of vitamin E that helps protect skin from environmental damage and supports moisture retention.
Irritation
low
Source
semi-synthetic
A gentle, water-soluble vitamin E derivative that offers antioxidant protection without the greasy feel of traditional vitamin E.
Irritation
low
Source
semi-synthetic
A modified, water-friendly form of vitamin E that may offer antioxidant benefits with less greasiness than traditional tocopherol.
Irritation
low
Source
semi-synthetic
Antioxidant
Tocopheryl Ethyl Succinate Ethyldimonium Ethosulfate
A modified vitamin E that sticks to hair and skin, offering antioxidant protection and conditioning without the greasy feel of plain vitamin E.
Irritation
low
Source
semi-synthetic
A cleverly designed antioxidant that pairs vitamins C and E in one stable molecule, offering dual protection without the typical instability of pure vitamin C.
Irritation
low
Source
semi-synthetic
A gentle, water-soluble vitamin E derivative that helps protect skin from environmental damage without the greasy feel of pure vitamin E.
Irritation
low
Source
semi-synthetic
A gentle, fat-soluble antioxidant that combines vitamin E with niacin to support skin health and circulation.
Irritation
low
Source
semi-synthetic
A stabilized, more skin-friendly version of vitamin E that may offer better antioxidant delivery with less irritation.
Irritation
low
Source
semi-synthetic
A gentle retinoid alternative that pairs vitamin A with vitamin E to support smoother, firmer-looking skin with less irritation than traditional retinol.
Irritation
low
Source
semi-synthetic
A stable, water-friendly version of vitamin E that helps protect skin from environmental damage without the greasy feel of traditional vitamin E.
Irritation
low
Source
semi-synthetic
A novel ingredient that pairs vitamin E with a brightening agent, but research is still limited compared to more established alternatives.
Irritation
low
Source
semi-synthetic
A gentle, silicone-bound vitamin E that delivers antioxidant protection with a smooth, non-greasy feel.
Irritation
low
Source
semi-synthetic
A gentle botanical extract with antioxidant potential, but research is limited and benefits are not yet well-established.
Irritation
low
Source
natural
Tolnaftate is a well-studied synthetic antifungal that effectively treats common fungal skin infections, but it is not a general skincare ingredient and should only be used for diagnosed fungal issues.
Irritation
low
Source
synthetic
Tolu Balsam Resin adds a warm, sweet scent to products but is a known allergen for some people, so it's best avoided in sensitive or fragrance-reactive skin.
Irritation
moderate
Source
natural
A synthetic fragrance ingredient that provides a sweet, almond-like scent but may cause skin irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
Toluene sulfonic acid is a synthetic pH adjuster that helps products maintain the right acidity, but it can be irritating at high concentrations.
Irritation
moderate
Source
synthetic
Antioxidant
Solanum Lycopersicum (Tomato) Callus Culture Conditioned Media
A plant-based biotech ingredient that may help shield skin from pollution and UV damage, but research is still early.
Irritation
low
Source
biotech
A gentle, plant-based antioxidant from tomato leaves that may help protect skin from environmental stress, though research is still early.
Irritation
low
Source
natural
A gentle, fermented antioxidant that may help brighten and protect skin, but research is still emerging.
Irritation
low
Source
biotech
Tomato fruit juice offers antioxidant and soothing benefits, but its effectiveness in skincare is modest compared to more concentrated vitamin C or lycopene extracts.
Irritation
low
Source
natural
A lightweight, antioxidant-rich oil that hydrates and softens skin without clogging pores.
Irritation
low
Source
natural
A gentle, hydrating water from tomatoes that offers light antioxidant benefits, but its effects are mild compared to more concentrated extracts.
Irritation
low
Source
natural
A gentle, antioxidant-rich plant extract that may help protect skin from environmental stress and soothe minor irritation.
Irritation
low
Source
natural
A gentle, lab-grown antioxidant from tomato leaves that helps defend skin against pollution and UV damage without irritation.
Irritation
low
Source
biotech