Phenylthioglycolic acid is a synthetic depilatory ingredient that breaks down hair keratin, but it can be irritating and is not intended for leave-on skincare.
Irritation
moderate
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Phenylthioglycolic acid is a synthetic depilatory ingredient that breaks down hair keratin, but it can be irritating and is not intended for leave-on skincare.
Irritation
moderate
Source
synthetic
Photosensitizer
PHEOPHORBIDE A AMIDO PEG-45 AMIDO DISTEAROYL GLYCEROPHOSPHOETHANE
A light-activated chlorophyll derivative that may boost collagen and reduce pigmentation, but requires professional handling due to potential irritation.
Irritation
moderate
Source
semi-synthetic
A gentle plant-root extract with early research suggesting antioxidant and soothing benefits, but human studies are limited.
Irritation
low
Source
natural
A gentle apple-derived antioxidant that helps even skin tone and defends against pollution and UV stress.
Irritation
low
Source
natural
A gentle apple-derived antioxidant that helps even skin tone and fights early signs of aging without irritation.
Irritation
low
Source
natural
A gentle, plant-derived antioxidant that may help brighten skin and reduce the look of dark spots without irritation.
Irritation
low
Source
natural
Phloroglucinol Trimethyl Ether is a synthetic antioxidant that may help protect skin from environmental stress, but research on its specific benefits in cosmetics is still limited.
Irritation
low
Source
synthetic
A gentle, plant-derived antioxidant extract that may help protect skin from environmental stress, though research is still emerging.
Irritation
low
Source
natural
A gentle, plant-based extract that may help calm skin and fight environmental stress, though research is still early.
Irritation
low
Source
natural
A gentle botanical extract with antioxidant potential, but research is still early and benefits are not yet proven in human skin.
Irritation
low
Source
natural
A fragrant wood oil with mild antimicrobial potential, best suited for those who enjoy botanical scents and have resilient skin.
Irritation
moderate
Source
natural
A gentle, hydrating mushroom extract that helps skin hold moisture and feel smooth, but research is still early.
Irritation
low
Source
natural
Phonolite is a natural volcanic mineral powder that gently exfoliates and absorbs excess oil without harsh chemicals.
Irritation
low
Source
natural
A gentle, antioxidant-rich ferment from blue-green algae that may help calm skin and defend against environmental stress.
Irritation
low
Source
biotech
A gentle, biotech-derived microalgae ferment that may help calm skin and fight oxidative stress, though research is still emerging.
Irritation
low
Source
biotech
A gentle, antioxidant-rich microalgae extract that may help calm skin and fight environmental stress, though research is still early.
Irritation
low
Source
natural
A gentle, antioxidant-rich algae extract that may help calm skin and fight environmental stress, but research is still early.
Irritation
low
Source
natural
A gentle, antioxidant-rich flower extract that may help soothe and protect skin, though research is still emerging.
Irritation
low
Source
natural
A gentle, plant-based extract that may help calm irritation and provide antioxidant protection, though human studies are limited.
Irritation
low
Source
natural
A gentle, hydrating plant juice that adds moisture and soothing benefits, but research on its efficacy is still limited.
Irritation
low
Source
natural
A gentle, natural exfoliant from New Zealand flax that helps polish skin without harsh microbeads.
Irritation
low
Source
natural
A gentle botanical extract with antioxidant potential, best for soothing sensitive or irritated skin, though research is still emerging.
Irritation
low
Source
natural
A gentle, plant-based emollient with antioxidant potential, but research on its specific benefits is still limited.
Irritation
low
Source
natural
A gentle, plant-derived antioxidant extract that may help calm and protect skin, though research is still early.
Irritation
low
Source
natural
A gentle, plant-based oil that helps soften and smooth skin without feeling heavy, though research on its specific benefits is still limited.
Irritation
low
Source
natural
Buffering Agent
Water, Sodium Chloride, Disodium Phosphate, Potassium Phosphate, Potassium Chloride
A gentle pH buffer and saline base that helps keep other ingredients stable and comfortable on skin.
Irritation
low
Source
synthetic
A gentle, naturally derived phospholipid that helps reinforce the skin barrier and improve moisture retention.
Irritation
low
Source
natural
A skin-friendly phospholipid that hydrates and helps other ingredients penetrate more effectively.
Irritation
low
Source
natural
A gentle, skin-identical phospholipid that supports barrier function and hydration without irritation.
Irritation
low
Source
natural
A gentle, skin-identical lipid that supports barrier function and hydration without clogging pores.
Irritation
low
Source
natural
Phosphatidylserine is a gentle, skin-identical lipid that helps strengthen the moisture barrier and soothe dryness, but its anti-aging benefits are still being studied.
Irritation
low
Source
natural
A gentle chelating agent that helps your products stay fresh and effective by neutralizing problematic metal ions.
Irritation
low
Source
synthetic
Phosphoric acid is a pH adjuster that helps keep products stable and effective, but it can be irritating at high concentrations.
Irritation
moderate
Source
synthetic
An experimental, cholesterol-linked RNA ingredient with potential for targeted skin delivery, but lacks broad safety and efficacy data for cosmetic use.
Irritation
moderate
Source
synthetic
Phosphorus pentoxide is a strong chemical used in tiny amounts to adjust pH, but it is not a direct skincare active and can be irritating if not properly diluted.
Irritation
high
Source
synthetic
Film Former
C4-18 ALKYL METHACRYLATE/METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE COPOLYMER
A gentle, biomimetic polymer that forms a protective film to lock in moisture and improve skin feel without irritation.
Irritation
low
Source
synthetic
Film Former
PHOSPHORYLCHOLINE GLYCOL METHACRYLATE/PEG-10 DIMETHACRYLATE CROSSPOLYMER
A gentle, biomimetic film-former that helps lock in moisture and improve skin feel without clogging pores.
Irritation
low
Source
synthetic
A gentle, plant-based extract that may help calm skin and fight free radicals, though research is still early.
Irritation
low
Source
natural
A safe, synthetic film former that helps products stay put without clogging pores or irritating skin.
Irritation
low
Source
synthetic
Phthalates are controversial synthetic chemicals linked to endocrine disruption; most are banned or restricted in cosmetics in many regions, but consumers should still check labels for hidden sources.
Irritation
low
Source
synthetic
Film Former
PHTHALIC ANHYDRIDE/BUTYL BENZOIC ACID/PROPYLENE GLYCOL COPOLYMER
A synthetic film-former that helps makeup and hair products last longer, but offers no skincare benefit and may feel heavy on some skin types.
Irritation
low
Source
synthetic
Film Former
PHTHALIC ANHYDRIDE/BENZOIC ACID/GLYCERIN COPOLYMER
A synthetic film-former that helps products stay put and resist water, but offers no active skincare benefit.
Irritation
low
Source
synthetic
Film Former
PHTHALIC ANHYDRIDE/GLYCERIN/GLYCIDYL DECANOATE COPOLYMER
A synthetic polymer that helps products stay put, but offers no active skincare benefit.
Irritation
low
Source
synthetic
A synthetic peroxide exfoliant that gently dissolves dead skin cells and helps fade dark spots, but may cause irritation in sensitive skin.
Irritation
moderate
Source
synthetic
A gentle marine extract that may help calm irritated skin and provide antioxidant support, though research is still emerging.
Irritation
low
Source
natural
A gentle, antioxidant-rich plant extract that may help calm and protect skin, though research is still early.
Irritation
low
Source
natural
Physalis Fruit Extract is a gentle, antioxidant-rich botanical that may help protect skin from environmental stress and calm minor irritation, though research is still emerging.
Irritation
low
Source
natural
A gentle, antioxidant-rich fruit extract that helps protect skin from environmental stress while providing mild soothing benefits.
Irritation
low
Source
natural
A gentle, plant-based extract from moss that may help calm skin and provide antioxidant protection, but research is still early.
Irritation
low
Source
natural
Phytantriol is a gentle, plant-derived humectant that helps hydrate and strengthen the skin barrier, making it a solid choice for most skin types.
Irritation
low
Source
natural
A mild, plant-derived exfoliant that brightens skin and boosts the effectiveness of other ingredients without the irritation of stronger acids.
Irritation
low
Source
natural
Phytin is a gentle, plant-derived ingredient that helps stabilize formulas and boost antioxidant protection without irritating skin.
Irritation
low
Source
natural
Phytoglobin is a plant-based protein that may help boost skin oxygenation and radiance, but research is still emerging and it's not a proven substitute for clinical treatments.
Irritation
low
Source
biotech
Phytol is a gentle antioxidant from chlorophyll that may help calm skin and fight signs of aging, but research is still early.
Irritation
low
Source
natural
A skin-friendly lipid that strengthens the barrier and helps calm redness without clogging pores.
Irritation
low
Source
biotech
A gentle, ceramide-like ingredient that strengthens the skin barrier and soothes sensitivity.
Irritation
low
Source
semi-synthetic
A gentle, dual-action ingredient that pairs barrier-strengthening lipids with stable vitamin C for antioxidant and brightening benefits.
Irritation
low
Source
semi-synthetic
A gentle, skin-identical lipid that helps strengthen the moisture barrier and calm sensitivity without clogging pores.
Irritation
low
Source
semi-synthetic
A skin-friendly lipid that strengthens the moisture barrier and calms sensitivity without clogging pores.
Irritation
low
Source
semi-synthetic
A skin-friendly lipid that strengthens the moisture barrier and soothes sensitivity without clogging pores.
Irritation
low
Source
biotech