A gentle, PEG-modified retinoid that may support smoother skin with less irritation than traditional retinol, but research is still emerging.
Irritation
low
Source
semi-synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A gentle, PEG-modified retinoid that may support smoother skin with less irritation than traditional retinol, but research is still emerging.
Irritation
low
Source
semi-synthetic
A synthetic silicone polymer that helps products spread smoothly and resist water, but may feel heavy on some skin types.
Irritation
low
Source
synthetic
A gentle, water-binding ingredient that helps keep products stable and skin hydrated, but its synthetic origin may not appeal to everyone.
Irritation
low
Source
synthetic
A gentle, water-attracting polymer that helps keep skin hydrated without clogging pores, but may not suit those avoiding all PEGs.
Irritation
low
Source
synthetic
A gentle synthetic polymer that helps products feel silky, spread evenly, and stay put without clogging pores.
Irritation
low
Source
synthetic
A gentle, water-soluble derivative of birch bark betulin that helps condition skin and form a light protective film, but research on its specific benefits is still limited.
Irritation
low
Source
semi-synthetic
A gentle film-forming ingredient derived from birch bark that helps skin feel smooth and protected, but research on its benefits is still limited.
Irritation
low
Source
semi-synthetic
A synthetic polymer that helps products spread smoothly, feel silky, and stay put without clogging pores.
Irritation
low
Source
synthetic
A synthetic humectant that helps keep skin hydrated and improves product texture, but may be less eco-friendly due to its PEG origin.
Irritation
low
Source
synthetic
A synthetic emulsifier that helps blend oil and water in cleansers, but may not suit those avoiding PEGs.
Irritation
low
Source
synthetic
A synthetic film-former that may help other ingredients stick to skin, but its large molecule size limits penetration and its safety data is still emerging.
Irritation
low
Source
synthetic
A synthetic polymer that helps products spread smoothly and form a light, flexible film on skin or hair, but its high molecular weight limits skin penetration and its safety data is still emerging.
Irritation
low
Source
synthetic
A gentle, stabilized vitamin C derivative that brightens and protects skin without the sting of pure L-ascorbic acid.
Irritation
low
Source
semi-synthetic
A gentle, semi-synthetic emollient that mimics natural skin lipids to soften and smooth skin without clogging pores.
Irritation
low
Source
semi-synthetic
Emollient
METHOXY PEG-8 DIMETHYLSILYLETHYL TRIMETHYLSILANE
A gentle silicone that improves product texture and leaves skin feeling smooth without clogging pores.
Irritation
low
Source
synthetic
Film Former
METHOXY PEG-17/METHOXY PEG-11/HDI ISOCYANURATE TRIMER CROSSPOLYMER
A synthetic polymer that helps products spread smoothly and stay put, but offers no active skincare benefit.
Irritation
low
Source
synthetic
A silicone emulsifier that helps blend water and oil phases, giving a silky, non-greasy feel with low irritation potential.
Irritation
low
Source
synthetic
A gentle silicone emulsifier that improves product texture and spreadability without clogging pores.
Irritation
low
Source
semi-synthetic
Conditioning Agent
METHOXY PEG/PPG-7/3 AMINOPROPYL DIMETHICONE
A gentle silicone that smooths hair and skin without heavy buildup, but may not suit those avoiding silicones or PEG compounds.
Irritation
low
Source
synthetic
Fragrance Ingredient
METHOXY-TETRAMETHYL-CYCLOHEXENYL METHYL KETONE
A synthetic fragrance ingredient that adds a pleasant floral-woody scent but offers no skincare benefits and may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
A synthetic fragrance ingredient with a strong odor; used in tiny amounts but may cause skin sensitivity in some people.
Irritation
moderate
Source
synthetic
A synthetic antioxidant that may help protect skin from environmental stress, but research is still limited.
Irritation
low
Source
synthetic
Methoxyacetophenone is a synthetic fragrance ingredient that adds a sweet, floral scent to products; it is generally considered safe at low levels but offers no direct skincare benefit.
Irritation
low
Source
synthetic
Anti-aging agent
Methoxybenzoyl Methylsulfonyl Oxopiperidinyl Piperazinecarboxamide
A lab-made compound that may help reduce deep wrinkles by interfering with muscle contraction signals, but human research is still limited.
Irritation
low
Source
synthetic
Methoxychalcone is a gentle antioxidant that may help calm skin and protect against environmental stress, but research is still emerging.
Irritation
low
Source
synthetic
Methoxycinnamal adds a cinnamon-like scent but can be a skin sensitizer, making it a potential concern for those with sensitive or allergy-prone skin.
Irritation
moderate
Source
synthetic
A cinnamon-derived antioxidant with antimicrobial potential, but its fragrance component can be irritating for sensitive skin.
Irritation
moderate
Source
natural
This synthetic compound is primarily used as a fragrance ingredient or fixative, but there is limited public research on its safety and efficacy in skincare.
Irritation
moderate
Source
synthetic
Methoxycinnamic acid is a gentle antioxidant that may offer mild UV protection and skin-brightening benefits, but it is not a primary sunscreen agent.
Irritation
low
Source
natural
Film Former
METHOXYCINNAMIDOPROPYL DIMETHYLAMINOBENZAMIDOPROPYL DIMETHICONOL
A multifunctional silicone that adds shine and softness to hair while offering some UV protection, but it is synthetic and not biodegradable.
Irritation
low
Source
synthetic
UV Absorber
DI-METHOXYCINNAMIDOPROPYL ETHYLDIMONIUM CHLORIDE ETHER
A synthetic UV-absorbing conditioner that helps protect hair and skin from sun damage while reducing static and improving feel.
Irritation
low
Source
synthetic
A dual-action ingredient that helps sunscreen spread evenly while adding a modest UV boost, but it is not a standalone sun protectant.
Irritation
low
Source
synthetic
Film Former
METHOXYCINNAMIDOPROPYL/PHENYL POLYSILSESQUIOXANE
A gentle silicone film-former that blurs imperfections and controls shine without clogging pores.
Irritation
low
Source
synthetic
A silicone-based UV filter that also improves product spreadability and water resistance, but its use is limited outside Asia.
Irritation
low
Source
synthetic
UV Absorber
METHOXYCINNAMOYLPROPYL SILSESQUIOXANE SILICATE
A silicone-bound UV filter that offers broad-spectrum protection with a lightweight, non-greasy feel.
Irritation
low
Source
synthetic
Fragrance Ingredient
6-DIETHOXYMETHYL-HEXAHYDRO-METHANO-1H-INDENE
A synthetic fragrance ingredient that adds a warm, woody scent; generally considered safe at low concentrations but may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
Methoxycitronellal is a synthetic fragrance ingredient that adds a fresh citrus scent but may cause skin irritation or allergic reactions in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic antioxidant that may help protect skin from environmental stress, but research is limited and it can be irritating for sensitive skin.
Irritation
moderate
Source
synthetic
A synthetic scent ingredient that gives a fresh, woody note but offers no skincare benefits.
Irritation
low
Source
synthetic
A synthetic emollient that helps products spread smoothly and leaves skin feeling soft, with a low risk of irritation.
Irritation
low
Source
synthetic
Methoxyethyl Acrylate is a synthetic film-former that helps nail products resist chipping and wear, but it can be a skin sensitizer for some individuals.
Irritation
moderate
Source
synthetic
Methoxyhexanethiol is a synthetic fragrance ingredient with limited safety data; it may cause skin irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic antioxidant that may help protect skin from environmental damage, but research is still emerging compared to more established antioxidants like vitamin C.
Irritation
low
Source
synthetic
Methoxyindane is a synthetic fragrance ingredient that adds a pleasant scent but offers no skincare benefits; it may be best for those who enjoy scented products and have no fragrance sensitivities.
Irritation
low
Source
synthetic
A synthetic solvent that helps products spread and dry, but may cause irritation for sensitive skin in high concentrations.
Irritation
moderate
Source
synthetic
A synthetic solvent and preservative that helps products stay fresh but may cause irritation for sensitive skin.
Irritation
moderate
Source
synthetic
A common synthetic fragrance ingredient that provides a pleasant floral scent but may cause skin irritation in sensitive individuals.
Irritation
moderate
Source
synthetic
A synthetic scent ingredient that adds a pleasant vanilla-like note but offers no skincare benefit and may trigger sensitivities in some people.
Irritation
low
Source
synthetic
A synthetic cooling ingredient that delivers a gentle, long-lasting chill without the strong smell or sting of menthol.
Irritation
low
Source
synthetic
A synthetic scent ingredient that adds a warm, sweet note to products; generally considered safe at low concentrations but may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
A stable synthetic antioxidant that helps defend skin against pollution and UV damage without common irritation.
Irritation
low
Source
synthetic
A synthetic UV filter that helps protect skin from sun damage, but its use is limited and less common than other filters.
Irritation
low
Source
synthetic
Skin conditioning agent
METHOXYPHENYLSULFONAMIDO DIHYDROXYPROPANAMIDE
A synthetic peptide-like ingredient that may help improve skin firmness, but research is still emerging and benefits are not yet proven in large human studies.
Irritation
low
Source
synthetic
A synthetic film-former that helps products stay put, but it's not a moisturizer or active ingredient.
Irritation
low
Source
synthetic
A synthetic fragrance ingredient that adds a fresh scent but offers no skincare benefits and may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
A synthetic scent ingredient that adds a fresh, green note but offers no skincare benefits and may cause sensitivity in some individuals.
Irritation
low
Source
synthetic
UV Filter
Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate
A modern synthetic UVA filter that provides broad-spectrum protection with low irritation potential, but its use is limited to certain regions due to regulatory approval status.
Irritation
low
Source
synthetic
A gentle, sugar-based humectant that hydrates without stickiness, suitable for most skin types including sensitive skin.
Irritation
low
Source
semi-synthetic
Methoxytridecene is a lightweight synthetic emollient that helps products glide on smoothly without a greasy feel, but it lacks strong research on long-term skin benefits.
Irritation
low
Source
synthetic
A synthetic scent ingredient that adds a pleasant floral note but offers no skincare benefit; safe at low levels but may cause sensitivity in some.
Irritation
low
Source
synthetic