Melatonin is a potent antioxidant that may help protect skin from environmental damage and support overnight repair, but more human studies are needed.
Irritation
low
Source
semi-synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
Melatonin is a potent antioxidant that may help protect skin from environmental damage and support overnight repair, but more human studies are needed.
Irritation
low
Source
semi-synthetic
Melibiose is a gentle sugar humectant that helps hydrate the skin and may support a healthy skin microbiome, making it a promising alternative to traditional humectants.
Irritation
low
Source
natural
A gentle plant extract with antioxidant potential, but research is still early and benefits are not yet proven in human studies.
Irritation
low
Source
natural
A gentle plant extract with antioxidant potential, but research is still early and benefits are not yet proven in human skin.
Irritation
low
Source
natural
Melilot Oil offers gentle soothing benefits and a pleasant herbal scent, but research on its cosmetic efficacy is still emerging.
Irritation
low
Source
natural
Melissa Leaf Oil offers a calming, herbal scent and antioxidant benefits, but its potency means it can be irritating for sensitive skin.
Irritation
moderate
Source
natural
A mild, aromatic botanical water that can soothe the skin and provide antioxidant benefits, but its effects are gentle and not a substitute for targeted treatments.
Irritation
low
Source
natural
Melissa oil offers a pleasant lemony scent and potential soothing benefits, but its high concentration of volatile compounds can be irritating for sensitive skin.
Irritation
moderate
Source
natural
A gentle, plant-based oil that softens skin and may offer mild antioxidant benefits, though research is still limited compared to more common seed oils.
Irritation
low
Source
natural
Melittin is a bee venom peptide with promising lab research, but it's a strong irritant and not well-studied in cosmetic use—caution is advised.
Irritation
high
Source
natural
Mellisic acid is a gentle wax-derived fatty acid that helps smooth and condition skin, but it's rarely used as a standalone active.
Irritation
low
Source
natural
A gentle, fermented melon extract that provides antioxidant benefits and supports skin hydration without irritation.
Irritation
low
Source
biotech
A gentle, plant-based antioxidant extract with limited but promising research; best as a supporting ingredient in antioxidant-rich formulas.
Irritation
low
Source
natural
A gentle, plant-based extract with antioxidant potential, but research on its specific skin benefits is still limited.
Irritation
low
Source
natural
A gentle plant-root extract with potential soothing and antioxidant benefits, but research is still early.
Irritation
low
Source
natural
Melozol Acetate is a synthetic emollient that helps soften and smooth skin with a low risk of irritation or clogged pores, though research on its long-term effects is limited.
Irritation
low
Source
synthetic
Melozol Formate is a gentle synthetic emollient that helps products feel silky and spread easily, but research on its long-term effects is still limited.
Irritation
low
Source
synthetic
Melozone is a gentle peptide-based brightener that may help fade dark spots over time, but clinical evidence is still limited compared to more established ingredients.
Irritation
low
Source
semi-synthetic
Menadione is a synthetic vitamin K3 with limited skincare benefits and notable safety concerns, making it a less common and cautious choice in modern formulations.
Irritation
moderate
Source
synthetic
Menaquinone-7 is a vitamin K2 form that may help firm skin and fade dark circles, but research in cosmetics is still early.
Irritation
low
Source
natural
A refreshing mint extract that can provide a cooling sensation, but may irritate sensitive skin due to its menthol content.
Irritation
moderate
Source
natural
A refreshing mint oil that can add a cooling feel to products but may irritate sensitive skin.
Irritation
moderate
Source
natural
A gentle botanical extract that may help calm irritation and provide antioxidant protection, but research is still early.
Irritation
low
Source
natural
A refreshing essential oil that adds a minty scent to products, but may irritate sensitive skin if used at high concentrations.
Irritation
moderate
Source
natural
A gentle mint extract that can provide a cooling sensation and mild soothing benefits, but is used more for sensory appeal than potent skincare action.
Irritation
low
Source
natural
A gentle botanical extract that may help calm skin and provide antioxidant support, but research is limited.
Irritation
low
Source
natural
A synthetic cooling agent that creates a refreshing, minty sensation without actual temperature change, ideal for post-exercise or warm-weather products.
Irritation
low
Source
synthetic
A synthetic cooling agent that provides a refreshing, non-minty cooling sensation, ideal for soothing or invigorating skincare products.
Irritation
low
Source
synthetic
A synthetic cooling ingredient that delivers a refreshing, non-minty sensation without the strong odor or volatility of menthol.
Irritation
low
Source
synthetic
Menthol provides a cooling, tingling sensation but can be irritating for sensitive skin at higher concentrations.
Irritation
moderate
Source
natural
Menthone provides a cooling, minty feel in skincare but can be irritating for sensitive skin at higher concentrations.
Irritation
moderate
Source
natural
A gentle, long-lasting cooling ingredient that adds a refreshing sensation without the strong odor or irritation of menthol.
Irritation
low
Source
synthetic
Menthyl acetate provides a mild cooling sensation without the strong minty odor of menthol, making it a gentle option for refreshing skincare products.
Irritation
low
Source
semi-synthetic
Menthyl Anthranilate is a gentle UVA sunscreen ingredient, but it is less common and not as broad-spectrum as newer alternatives.
Irritation
low
Source
synthetic
A synthetic cooling agent that provides a long-lasting, non-minty cooling feel, ideal for after-sun or refreshing skincare products.
Irritation
low
Source
synthetic
A gentle synthetic cooling ingredient that provides a refreshing sensation without the strong minty smell or potential irritation of menthol.
Irritation
low
Source
synthetic
Menthyl isovalerate is a gentle synthetic cooling ingredient that provides a refreshing sensation without the strong minty smell or potential irritation of menthol.
Irritation
low
Source
synthetic
Menthyl lactate is a gentle cooling ingredient that provides a refreshing sensation without the strong minty smell, making it ideal for sensitive skin or products where fragrance is minimized.
Irritation
low
Source
semi-synthetic
Menthyl nicotinate creates a temporary warm or tingly feeling by increasing blood flow to the skin, but it offers no lasting cosmetic benefit and can irritate sensitive skin.
Irritation
moderate
Source
synthetic
Menthyl PCA offers a gentle, long-lasting cooling sensation without the strong minty odor of menthol, while also helping to hydrate the skin.
Irritation
low
Source
semi-synthetic
A gentle synthetic cooling ingredient that adds a refreshing feel to skincare without the strong mint scent or irritation potential of menthol.
Irritation
low
Source
synthetic
A gentle, cooling emollient that hydrates and soothes without greasiness, ideal for sensitive or overheated skin.
Irritation
low
Source
semi-synthetic
Menthyl salicylate creates a cooling tingle on skin, but can be irritating for sensitive types and is not a proven treatment for pain or inflammation.
Irritation
moderate
Source
synthetic
Menthyl Succinate is a gentle, synthetic cooling ingredient that provides a refreshing sensation without the strong minty smell or irritation potential of menthol.
Irritation
low
Source
synthetic
A synthetic fragrance ingredient with limited safety data; best for those who tolerate fragrance well.
Irritation
moderate
Source
synthetic
A synthetic antioxidant that may help protect skin from environmental stress, but research is still limited compared to more established antioxidants.
Irritation
low
Source
synthetic
A gentle red algae extract that helps hydrate and calm the skin, though research is still emerging.
Irritation
low
Source
natural
Meroxapol 105 is a synthetic ingredient that helps mix oil and water in cleansers and lotions, with a low risk of irritation.
Irritation
low
Source
synthetic
A mild synthetic surfactant that helps cleanse and emulsify without stripping the skin, but offers no active skincare benefits.
Irritation
low
Source
synthetic
A mild synthetic ingredient that helps mix oil and water in cleansers, but offers no direct skin benefit.
Irritation
low
Source
synthetic
Meroxapol 172 is a gentle synthetic emulsifier that helps mix water and oil in cleansers and lotions, with low irritation potential.
Irritation
low
Source
synthetic
A mild synthetic surfactant that helps blend oil and water in cleansers, generally well-tolerated but not a standout active ingredient.
Irritation
low
Source
synthetic
A gentle synthetic surfactant that helps cleanse without stripping the skin, but offers no active skincare benefits.
Irritation
low
Source
synthetic
A mild synthetic surfactant that helps blend oil and water in cleansers, generally well-tolerated but not a standout active ingredient.
Irritation
low
Source
synthetic
Meroxapol 252 is a gentle synthetic surfactant that helps blend oil and water in cleansers, but it offers no direct skin benefit beyond cleansing.
Irritation
low
Source
synthetic
Meroxapol 254 is a gentle synthetic surfactant that helps cleanse and stabilize formulas, but it's not a star active ingredient.
Irritation
low
Source
synthetic
A mild synthetic surfactant that helps blend oil and water in cleansers, generally considered gentle and low-irritation.
Irritation
low
Source
synthetic
A gentle synthetic surfactant that helps blend oil and water in cleansers, with low irritation potential.
Irritation
low
Source
synthetic
Meroxapol 311 is a gentle synthetic surfactant that helps cleansers foam and rinse cleanly, but it offers no direct skin benefit beyond cleansing.
Irritation
low
Source
synthetic
Meroxapol 312 is a gentle synthetic surfactant that helps cleansers foam and rinse cleanly, but it offers no direct skin benefit beyond cleansing.
Irritation
low
Source
synthetic