A lab-made peptide that signals skin to appear firmer and smoother, with low irritation potential.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A lab-made peptide that signals skin to appear firmer and smoother, with low irritation potential.
Irritation
low
Source
synthetic
A synthetic peptide that may help support collagen and improve skin firmness with low irritation risk.
Irritation
low
Source
synthetic
A synthetic peptide that may help soften fine lines and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help smooth wrinkles and improve skin firmness with a low risk of irritation.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation potential.
Irritation
low
Source
synthetic
A gentle, melatonin-inspired ingredient that may help calm skin and support overnight repair, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that mimics natural signals to encourage firmer, smoother-looking skin over time.
Irritation
low
Source
synthetic
A well-studied peptide that may help reduce fine lines and support firmer-looking skin with consistent use.
Irritation
low
Source
synthetic
Skin conditioning agent
Palmitoyl SH-Polypeptide-109 Cholesterol
A synthetic peptide-cholesterol hybrid that may help improve skin firmness and hydration, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften fine lines, but more independent human studies are needed.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce the appearance of fine lines and improve skin firmness, but results are gradual and vary by person.
Irritation
low
Source
synthetic
A synthetic peptide that signals skin to produce more collagen, helping soften fine lines over time with minimal irritation.
Irritation
low
Source
synthetic
A gentle peptide that may help soften fine lines by encouraging collagen production, but results are subtle and take time.
Irritation
low
Source
synthetic
A gentle peptide that may help improve skin firmness and soften fine lines with consistent use.
Irritation
low
Source
synthetic
A well-studied peptide that helps calm skin and support collagen production, making it a gentle anti-aging workhorse.
Irritation
low
Source
synthetic
Palmitoyl Tripeptide-4 is a well-studied peptide that helps reduce fine lines and improve skin firmness by encouraging collagen production.
Irritation
low
Source
synthetic
Anti-aging
Palmitoyl Tripeptide-5 Amidopropyl Ascorbyl Phosphate HCl
A clever combo ingredient that pairs a collagen-boosting peptide with a stable form of vitamin C for dual anti-aging and antioxidant benefits.
Irritation
low
Source
semi-synthetic
A synthetic peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with low irritation risk.
Irritation
low
Source
synthetic
A synthetic peptide that helps calm visible skin reactivity and supports a more resilient-looking complexion over time.
Irritation
low
Source
synthetic
A synthetic peptide that pairs vitamin B5 with amino acids to help strengthen the skin barrier and improve hydration, though research is still emerging.
Irritation
low
Source
synthetic
A novel biotech peptide that may help strengthen the skin barrier and reduce fine lines, but research is still early.
Irritation
low
Source
biotech
A lab-made peptide inspired by bee venom that aims to smooth and firm skin, but human research is very limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation risk.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and reduce fine lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but human data is still limited compared to well-studied peptides.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften expression lines, but results are subtle and require consistent use.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften fine lines, but research is still emerging.
Irritation
low
Source
synthetic
Pentapeptide-61 is a lab-made peptide that may help reduce fine lines and improve skin firmness by signaling collagen production, but human studies are limited.
Irritation
low
Source
synthetic
Skin conditioning agent
Escherichia Coli Thioredoxin-1, Heptapeptide-20, Hexapeptide-40, Oligopeptide-113, Sh-Polypeptide-70
A cutting-edge peptide blend that may support skin firmness, but research is still emerging and the complex formulation makes it hard to evaluate.
Irritation
low
Source
biotech
Skin conditioning agent
R-(SH-POLYPEPTIDE-102 METHIONYL S-PENTADIPLANDRA BRAZZEANA DEFENSIN-LIKE PROTEIN)
A novel peptide-protein hybrid with promising but limited research; may help support skin resilience.
Irritation
low
Source
semi-synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with a good safety profile for most skin types.
Irritation
low
Source
synthetic
A peptide from porcine sources that may help support skin firmness, but research is limited and ethical concerns exist.
Irritation
low
Source
natural
A gentle, niacinamide-derived peptide that may help brighten skin and reduce signs of aging with low irritation risk.
Irritation
low
Source
semi-synthetic
A gentle, plant-derived peptide that may help support skin firmness and a more youthful look, though research is still emerging.
Irritation
low
Source
biotech
A gentle, plant-derived peptide that may help improve skin hydration and firmness, but research is still limited.
Irritation
low
Source
natural
A gentle, plant-based peptide that may help improve skin firmness, but research is still limited.
Irritation
low
Source
natural
A gentle, plant-derived peptide that may help support skin firmness and reduce fine lines, though research is still emerging.
Irritation
low
Source
biotech
A synthetic peptide that may help reduce signs of aging and calm skin, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help support skin firmness and reduce fine lines, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and smooth fine lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce the look of fine lines, but research is limited and mostly based on similar peptides.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm and repair skin, but human studies are limited and it's not a medical treatment.
Irritation
low
Source
biotech
A novel yeast-derived peptide that may help improve skin firmness, but research is still early and benefits are not yet proven in large human studies.
Irritation
low
Source
biotech
A novel peptide from fish that may support skin firmness and repair, but human research is very limited.
Irritation
low
Source
natural
Anti-aging agent
SR-RAINBOW TROUT OLIGOPEPTIDE-1 SH-POLYPEPTIDE-8
A novel peptide complex derived from rainbow trout proteins that may support skin firmness and repair, but research is very limited and mostly theoretical.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and reduce fine lines, but human research is still limited.
Irritation
low
Source
biotech
A gentle peptide-retinoid hybrid that aims to support smoother, firmer-looking skin without the harsh side effects of traditional retinoids.
Irritation
low
Source
synthetic
A gentle peptide-retinoid hybrid that supports collagen without the harsh side effects of pure retinol.
Irritation
low
Source
semi-synthetic
RH-Polypeptide-104 is a lab-made peptide that may help support collagen and improve skin firmness, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help reduce fine lines and improve skin firmness, but research is still emerging.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and reduce fine lines, with low irritation risk.
Irritation
low
Source
biotech
A promising synthetic peptide that may help firm skin and reduce fine lines, but human research is still limited.
Irritation
low
Source
biotech
A lab-made peptide that may help firm skin and soften wrinkles, but human studies are still limited.
Irritation
low
Source
synthetic
A lab-made peptide that may help reduce fine lines and improve skin firmness, but human research is still limited.
Irritation
low
Source
synthetic
RH-Polypeptide-94 is a synthetic peptide that may help firm skin and soften fine lines, but research is still early.
Irritation
low
Source
biotech
A promising synthetic peptide that may help firm and smooth skin, but research is still early and benefits vary by formulation.
Irritation
low
Source
semi-synthetic
A gentle, rice-derived peptide that may help improve skin firmness and reduce fine lines with regular use.
Irritation
low
Source
biotech
A gentle, bioengineered peptide that may help support skin firmness, but research is still emerging.
Irritation
low
Source
biotech
A gentle rice-derived peptide that may help improve skin firmness and reduce fine lines, though human studies are still limited.
Irritation
low
Source
biotech