A lab-made peptide that may help support collagen and reduce fine lines, but human studies are limited.
Irritation
low
Source
synthetic
Beauty ingredient research
Browse the review database to understand what an ingredient is, what it does in a beauty formula, when it is useful, and when it deserves caution across skincare, haircare, bodycare, makeup, and more.
20769
Reviewed ingredients
524
Low-concern standouts
2884
Need usage caution
A lab-made peptide that may help support collagen and reduce fine lines, but human studies are limited.
Irritation
low
Source
synthetic
Decapeptide-37 is a lab-made peptide that may help support collagen and firm skin, but research is still early and results vary.
Irritation
low
Source
synthetic
A lab-made peptide that may help reduce fine lines and improve skin firmness, but human studies are limited.
Irritation
low
Source
synthetic
Decapeptide-45 is a lab-made peptide that may help support firmer, smoother skin, but research is still early and results vary.
Irritation
low
Source
synthetic
Decapeptide-46 is a lab-made peptide that may help support collagen and elastin for firmer skin, but research is still early.
Irritation
low
Source
synthetic
Skin conditioning agent
Deer Antler Blood/Cell Culture Conditioned Media
A novel biotech ingredient with potential regenerative benefits, but human evidence is very limited and ethical sourcing is a concern.
Irritation
low
Source
biotech
Anti-aging agent
DEER ANTLER CELL/SH-POLYPEPTIDE-1 CONDITIONED MEDIA
A novel biotech ingredient with promising anti-aging potential, but human research is still limited.
Irritation
low
Source
biotech
Deer antler velvet extract is a trendy but poorly studied ingredient in skincare, with anecdotal anti-aging claims and significant ethical baggage.
Irritation
low
Source
natural
A novel biotech ingredient with promising regenerative potential, but human skincare evidence is still very limited.
Irritation
low
Source
biotech
A stabilized collagen derivative that may help support skin firmness and hydration with a lower risk of irritation than traditional collagen.
Irritation
low
Source
biotech
A gentle, synthetic amino-acid derivative that may help soften the look of fine lines, but research is still early.
Irritation
low
Source
synthetic
A synthetic ingredient that may help improve skin firmness and reduce fine lines, but research is still limited compared to more established peptides.
Irritation
low
Source
synthetic
A sugar-modified peptide that may help firm skin and soften fine lines with low irritation potential.
Irritation
low
Source
synthetic
Anti-aging agent
DIHYDROXYBENZYL ADAMANTANYLDIMETHOXYBENZAMIDE
A lab-made molecule that aims to mimic the skin-firming effects of certain peptides, but human research is still limited.
Irritation
low
Source
synthetic
DMAE tartrate can give a temporary firming sensation, but results are short-lived and may cause irritation for some.
Irritation
moderate
Source
semi-synthetic
A novel ingredient that may support collagen and skin firmness, but human research is still limited.
Irritation
low
Source
semi-synthetic
A gentle, collagen-supporting ingredient that helps improve skin firmness and elasticity with low irritation risk.
Irritation
low
Source
semi-synthetic
A lab-made peptide that may help firm skin and soften lines, but human studies are limited.
Irritation
low
Source
synthetic
A synthetic ingredient that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic ingredient that may support skin firmness and smoothness, but research is still emerging.
Irritation
low
Source
synthetic
Diretinyl ether is a synthetic retinoid derivative that may offer anti-aging benefits similar to retinol, but with less irritation potential, though research is still emerging.
Irritation
moderate
Source
synthetic
Skin conditioning agent
Disodium Tetramethylhexadecenyl Succinoyl Cysteine
A lab-made compound that mimics a skin-signaling peptide to help improve firmness and smoothness, but human studies are limited.
Irritation
low
Source
synthetic
Anti-wrinkle agent
Disodium Tetramethylhexadecenylcysteine Formylprolinate
A synthetic peptide-like ingredient that may help soften expression lines, but research is limited and results vary.
Irritation
low
Source
synthetic
Elastin is a natural protein that helps skin stay firm and bouncy, but its large molecule size limits deep penetration when applied topically.
Irritation
low
Source
natural
A novel, biotech-derived ingredient with limited human research; may support skin repair but lacks robust clinical evidence.
Irritation
low
Source
biotech
A milder retinoid that aims to deliver anti-aging results with less irritation than traditional retinol, making it a good option for sensitive skin.
Irritation
low
Source
semi-synthetic
A synthetic peptide-like ingredient that may help soften expression lines by temporarily relaxing facial muscles, similar to a milder, topical alternative to injectables.
Irritation
low
Source
synthetic
Skin conditioning agent
ETHYLARGININOATE ACETAMIDOMETHIONAMIDE HCL
A synthetic peptide-like ingredient that may help improve skin firmness and reduce wrinkle depth, but human data is limited.
Irritation
low
Source
synthetic
A synthetic peptide-like ingredient that may help soften expression lines, but results are subtle and not as dramatic as prescription treatments.
Irritation
low
Source
synthetic
A synthetic peptide with iron that may help support skin firmness, but research is still early and benefits are not guaranteed.
Irritation
low
Source
synthetic
Anti-Aging Agent
HUMAN FIBROBLAST INDUCED PLURIPOTENT CELL CULTURE CONDITIONED MEDIA
A cutting-edge biotech ingredient that may support skin repair and reduce signs of aging, but human research is still limited and products are often very expensive.
Irritation
low
Source
biotech
A synthetic plant hormone derivative that may help firm and smooth skin, but human research is limited.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed to confirm its effectiveness.
Irritation
low
Source
synthetic
A lab-made peptide that may help firm skin and soften lines, but human studies are still limited.
Irritation
low
Source
synthetic
A promising synthetic peptide that may help firm skin and soften wrinkles, but more independent human studies are needed to confirm its effects.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more independent research is needed.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, with good tolerability for most skin types.
Irritation
low
Source
synthetic
A gentler alternative to retinol that targets collagen support, but research is still early and results may vary.
Irritation
low
Source
synthetic
Gibberellic acid is a plant-derived ingredient that may help boost collagen and elastin, but research is still early and it's not a proven anti-aging powerhouse.
Irritation
low
Source
natural
A promising anti-glycation ingredient that may help prevent skin stiffness and dullness caused by sugar damage, though research is still emerging.
Irritation
low
Source
synthetic
A gentle retinoid alternative that delivers anti-aging benefits with less irritation than traditional retinol.
Irritation
low
Source
semi-synthetic
A gentle, lab-made amino acid derivative that may help improve skin firmness and smoothness, but research is still early.
Irritation
low
Source
semi-synthetic
Anti-aging agent
GUANIDINOPENTYL PHENYLISOXAZOLECARBOXAMIDE
A synthetic peptide-like ingredient that may help firm skin and reduce wrinkles, but research is still early.
Irritation
low
Source
synthetic
A synthetic peptide that may help smooth fine lines and support skin firmness with a low risk of irritation.
Irritation
low
Source
synthetic
A synthetic peptide designed to support collagen and reduce fine lines, generally well-tolerated but with limited independent research.
Irritation
low
Source
synthetic
Heptapeptide-17 is a synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Heptapeptide-28 is a synthetic peptide that may help reduce fine lines and improve skin firmness, with low irritation risk and moderate research support.
Irritation
low
Source
synthetic
Heptapeptide-31 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still emerging and results vary.
Irritation
low
Source
synthetic
Heptapeptide-32 is a synthetic peptide that may help reduce fine lines and improve skin firmness by signaling collagen production, but research is still emerging.
Irritation
low
Source
synthetic
Heptapeptide-34 is a lab-made peptide that may help support skin structure, but research is still early and results vary.
Irritation
low
Source
synthetic
Heptapeptide-35 is a synthetic peptide that may help reduce the appearance of fine lines by signaling skin to support collagen, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften wrinkles, but research is still early.
Irritation
low
Source
synthetic
Heptapeptide-37 is a synthetic peptide that may help support skin firmness and reduce fine lines, but research is still limited compared to more established peptides.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and smooth fine lines, but research is still emerging.
Irritation
low
Source
synthetic
A synthetic peptide that signals skin to produce more collagen, helping to soften wrinkles and improve firmness over time.
Irritation
low
Source
synthetic
A synthetic peptide that may help firm skin and soften lines, but research is still early and results vary.
Irritation
low
Source
synthetic
A synthetic peptide that may help improve skin firmness and reduce fine lines, but more human studies are needed.
Irritation
low
Source
synthetic
Heptapeptide-41 is a promising synthetic peptide that may help firm skin and soften wrinkles, but research is still early and results vary.
Irritation
low
Source
synthetic