Ingredient review
Sodium Histidyl Hyaluronate Crosspolymer-3
INCI: SODIUM HISTIDYL HYALURONATE CROSSPOLYMER-3
A high-tech hyaluronic acid that binds moisture to skin longer than standard HA, with added antioxidant benefits from histidine.
In plain English
This is a modified version of hyaluronic acid (a natural moisture-binding molecule in your skin) that has been crosslinked and attached to histidine (an amino acid). The crosslinking makes it larger and stickier, so it stays on the skin surface longer and doesn't rinse away easily. The histidine part helps protect skin from free radical damage. Together, they provide intense, lasting hydration without the sticky feel of some other HA derivatives.
Review score
Safety, usefulness, and evidence
Strong fit for many routines
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- semi synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Easy yes for most routines
Sodium Histidyl Hyaluronate Crosspolymer-3 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Sodium Histidyl Hyaluronate Crosspolymer-3.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
A semi-synthetic polymer created by crosslinking hyaluronic acid with histidine, an amino acid. This structure creates a larger molecule that forms a breathable, hydrating film on the skin.
How it works
When applied, it forms a flexible film on the skin that holds water and slowly releases it over time. The crosslinked structure resists being washed off by sweat or water, so hydration lasts longer. The histidine component also acts as an antioxidant, neutralizing some free radicals that cause premature aging.
Pros
Longer-lasting hydration
The crosslinked structure holds water on the skin longer than standard hyaluronic acid, reducing the need for frequent reapplication.
Antioxidant bonus
The histidine component provides antioxidant activity, helping to protect skin from environmental stressors like pollution and UV.
Cons and cautions
Less research than standard HA
While promising, this specific crosspolymer has fewer peer-reviewed studies compared to traditional hyaluronic acid, so long-term data is limited.
Potential tackiness
In higher concentrations or layered with other thick products, it may leave a slightly tacky feel until fully absorbed.
Best for
- People with dry or dehydrated skin looking for extended moisture
- Those who want antioxidant benefits in a hydrating ingredient
Use caution if
- Individuals with known allergy to hyaluronic acid or histidine (rare)
Usage tips
Safety summary
Considered safe for topical use. Low irritation and comedogenic risk. No significant safety concerns reported in cosmetic concentrations.
Research notes
Moderate evidence supports its superior water-binding capacity and antioxidant activity compared to standard hyaluronic acid. Most data comes from manufacturer studies and a few independent evaluations.
Common label clues
- Typical concentration
- 0.1% to 2%
- Regulatory status
- Approved for cosmetic use globally; no specific restrictions in the EU, US, or Asia.
- Common uses
- Serums, Moisturizers, Eye creams, Sheet masks
- Environmental note
- Produced via controlled chemical modification; no known environmental persistence concerns at cosmetic use levels.
Good to know
- This ingredient is often used in 'next-gen' HA serums that claim 24-hour hydration.
- It is compatible with most other skincare ingredients, including vitamin C and retinol.
Common questions
What is Sodium Histidyl Hyaluronate Crosspolymer-3 in beauty products?
This is a modified version of hyaluronic acid (a natural moisture-binding molecule in your skin) that has been crosslinked and attached to histidine (an amino acid). The crosslinking makes it larger and stickier, so it stays on the skin surface longer and doesn't rinse away easily. The histidine part helps protect skin from free radical damage. Together, they provide intense, lasting hydration without the sticky feel of some other HA derivatives.
What does Sodium Histidyl Hyaluronate Crosspolymer-3 do in a beauty product?
When applied, it forms a flexible film on the skin that holds water and slowly releases it over time. The crosslinked structure resists being washed off by sweat or water, so hydration lasts longer. The histidine component also acts as an antioxidant, neutralizing some free radicals that cause premature aging.
Is Sodium Histidyl Hyaluronate Crosspolymer-3 safe for most people?
Considered safe for topical use. Low irritation and comedogenic risk. No significant safety concerns reported in cosmetic concentrations.
Who should be careful with Sodium Histidyl Hyaluronate Crosspolymer-3?
Individuals with known allergy to hyaluronic acid or histidine (rare)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.