Ingredient review
Silkworm Polypeptide-47
INCI: SILKWORM RH-POLYPEPTIDE-47
A gentle, biotech-derived peptide that helps hydrate and condition skin, but research on its specific benefits is still limited.
In plain English
This ingredient is a lab-made protein fragment inspired by silkworm silk. In skincare, it acts like a sponge to attract moisture to the skin's surface, helping it feel softer and smoother. It's a modern alternative to traditional silk proteins, designed to be more consistent and less likely to cause irritation.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is still emerging, so marketing claims deserve extra caution.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- biotech
- Evidence
- emerging
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Silkworm Polypeptide-47 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Silkworm Polypeptide-47.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
A recombinant (lab-created) polypeptide derived from silkworm proteins, produced through biotechnology for use in cosmetic formulations.
How it works
It forms a thin, moisture-retaining film on the skin, reducing water loss and temporarily plumping the skin's surface. It may also support the skin's natural barrier function by providing amino acids that help maintain healthy skin cells.
Pros
Gentle hydration
Provides moisture without common irritants, making it suitable for sensitive or reactive skin types.
Biotech sustainability
Produced via fermentation rather than harvesting from silkworms, reducing environmental impact and ensuring consistent quality.
Cons and cautions
Limited research
Most evidence comes from lab studies or small trials; large-scale human studies on anti-aging or long-term benefits are lacking.
Variable efficacy
Its performance heavily depends on the product formulation and concentration, so not all products containing it will deliver noticeable results.
Best for
- People with dry or dehydrated skin looking for a gentle humectant
- Those interested in biotech-derived, sustainable ingredients
Use caution if
- Individuals with known allergies to silkworm-derived proteins (rare)
Usage tips
Safety summary
Considered safe for topical use with a low risk of irritation or allergic reaction. No significant safety concerns have been reported in cosmetic applications.
Research notes
Research is in early stages. Preliminary studies suggest moisturizing and skin-conditioning benefits, but more robust clinical trials are needed to confirm efficacy.
Common label clues
- Typical concentration
- Typically used at 0.1% to 2% in leave-on products
- Regulatory status
- Generally recognized as safe for cosmetic use in the US and EU when used as intended, though it is not specifically approved by the FDA for any medical claim.
- Common uses
- Serums, Moisturizers, Anti-aging creams
- Environmental note
- Produced via biotechnology, which typically has a lower environmental footprint than animal-derived silk proteins.
Good to know
- This ingredient is often listed near the end of an ingredient list, indicating a low concentration
- It is not the same as whole silk protein; it's a specific peptide fragment
Common questions
What is Silkworm Polypeptide-47 in beauty products?
This ingredient is a lab-made protein fragment inspired by silkworm silk. In skincare, it acts like a sponge to attract moisture to the skin's surface, helping it feel softer and smoother. It's a modern alternative to traditional silk proteins, designed to be more consistent and less likely to cause irritation.
What does Silkworm Polypeptide-47 do in a beauty product?
It forms a thin, moisture-retaining film on the skin, reducing water loss and temporarily plumping the skin's surface. It may also support the skin's natural barrier function by providing amino acids that help maintain healthy skin cells.
Is Silkworm Polypeptide-47 safe for most people?
Considered safe for topical use with a low risk of irritation or allergic reaction. No significant safety concerns have been reported in cosmetic applications.
Who should be careful with Silkworm Polypeptide-47?
Individuals with known allergies to silkworm-derived proteins (rare)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.