Ingredient review
SH-Polypeptide-98 Hexapeptide-40
INCI: SH-Polypeptide-98, Hexapeptide-40
A synthetic peptide duo that may help soften fine lines and support firmer-looking skin, though long-term human data is still emerging.
In plain English
Peptides are short chains of amino acids that act as building blocks for proteins like collagen. SH-Polypeptide-98 and Hexapeptide-40 are lab-made peptides designed to signal skin cells to produce more collagen and elastin, which can help reduce the look of wrinkles and improve skin firmness over time.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
SH-Polypeptide-98 Hexapeptide-40 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging SH-Polypeptide-98 Hexapeptide-40.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
A combination of two synthetic peptides (SH-Polypeptide-98 and Hexapeptide-40) engineered to mimic natural signaling molecules that encourage collagen synthesis in the skin.
How it works
When applied topically, these peptides are thought to penetrate the outer layer of skin and bind to receptors on fibroblasts, triggering them to produce more collagen and elastin. This can help plump the skin and reduce the depth of fine lines with consistent use.
Pros
Targets collagen production
These peptides are designed to signal skin cells to produce more collagen, which can help reduce fine lines and improve firmness over time.
Low irritation potential
Synthetic peptides are generally well-tolerated and unlikely to cause stinging or redness, making them suitable for sensitive skin types.
Cons and cautions
Results take time
Peptides work gradually, and visible improvements in wrinkles typically require several weeks to months of daily use.
Limited human research
While lab studies are promising, there are fewer large-scale human trials specifically on SH-Polypeptide-98 and Hexapeptide-40 compared to more established peptides.
Best for
- Adults looking to reduce early signs of aging
- Those wanting a non-irritating anti-aging ingredient
Use caution if
- Individuals with known allergies to synthetic peptides (rare)
- Those seeking immediate results (peptides require consistent use)
Usage tips
Safety summary
SH-Polypeptide-98 and Hexapeptide-40 are considered safe for topical cosmetic use. They have low irritation and comedogenic potential, and no significant safety concerns have been reported in available literature.
Research notes
Research on these specific peptides is limited, but the broader class of signal peptides has moderate evidence supporting their ability to stimulate collagen production and reduce wrinkle depth in human studies.
Common label clues
- Typical concentration
- 0.1% to 1%
- Regulatory status
- Generally recognized as safe for cosmetic use in the US and EU when formulated within recommended concentrations.
- Common uses
- Anti-aging serums, Eye creams, Facial moisturizers
- Environmental note
- Synthetic peptides are produced via laboratory synthesis, which reduces the need for animal-derived or plant-based raw materials, but the manufacturing process has an energy footprint.
Good to know
- Peptides are often listed near the middle or end of ingredient lists because they are effective at low concentrations.
- Store peptide products away from direct sunlight and heat to maintain stability.
Common questions
What is SH-Polypeptide-98 Hexapeptide-40 in beauty products?
Peptides are short chains of amino acids that act as building blocks for proteins like collagen. SH-Polypeptide-98 and Hexapeptide-40 are lab-made peptides designed to signal skin cells to produce more collagen and elastin, which can help reduce the look of wrinkles and improve skin firmness over time.
What does SH-Polypeptide-98 Hexapeptide-40 do in a beauty product?
When applied topically, these peptides are thought to penetrate the outer layer of skin and bind to receptors on fibroblasts, triggering them to produce more collagen and elastin. This can help plump the skin and reduce the depth of fine lines with consistent use.
Is SH-Polypeptide-98 Hexapeptide-40 safe for most people?
SH-Polypeptide-98 and Hexapeptide-40 are considered safe for topical cosmetic use. They have low irritation and comedogenic potential, and no significant safety concerns have been reported in available literature.
Who should be careful with SH-Polypeptide-98 Hexapeptide-40?
Individuals with known allergies to synthetic peptides (rare) Those seeking immediate results (peptides require consistent use)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.