Ingredient review
SH-Polypeptide-97
INCI: SH-Polypeptide-97
SH-Polypeptide-97 is a lab-made peptide that may help reduce fine lines by encouraging the skin to produce more collagen, though research is still early.
In plain English
SH-Polypeptide-97 is a short chain of amino acids (the building blocks of protein) made in a lab. When applied to the skin in a cream or serum, it acts like a tiny messenger that tells skin cells to ramp up collagen production. More collagen means firmer, plumper skin and fewer fine lines over time. Because it's synthetic, it's very stable in formulas and unlikely to cause irritation.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is still emerging, so marketing claims deserve extra caution.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- emerging
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
SH-Polypeptide-97 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging SH-Polypeptide-97.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
A synthetic peptide, specifically a hexapeptide (six amino acids linked together), designed to mimic natural signaling molecules in the skin that trigger collagen synthesis.
How it works
It binds to receptors on fibroblasts (the cells that make collagen) and signals them to produce more collagen and other structural proteins. This helps reinforce the skin's support network, reducing the appearance of wrinkles and improving elasticity.
Pros
Gentle on skin
Unlike some anti-aging actives, SH-Polypeptide-97 rarely causes stinging, redness, or peeling, making it suitable for sensitive skin types.
Targets collagen production
It works at the cellular level to encourage your skin to build its own collagen, which is a more sustainable approach than simply coating the surface.
Cons and cautions
Slow to show results
Peptides generally take 4–12 weeks of consistent use before you see visible improvement in lines or firmness. It's not a quick fix.
Limited independent research
Most studies on SH-Polypeptide-97 are manufacturer-funded, and there are few peer-reviewed human trials available to confirm its efficacy.
Best for
- People looking for a gentle anti-aging ingredient
- Those with sensitive skin who want to avoid strong retinoids or acids
Use caution if
- Anyone allergic to synthetic peptides (rare)
- Those expecting immediate, dramatic results
Usage tips
Safety summary
SH-Polypeptide-97 is considered safe for cosmetic use at typical concentrations. It has a low irritation and comedogenic profile, and no significant safety concerns have been reported in available literature.
Research notes
Evidence is primarily from manufacturer studies and in vitro research showing collagen stimulation. Human clinical data is limited but promising for mild anti-aging effects. More independent peer-reviewed studies are needed.
Common label clues
- Typical concentration
- Typically used at 0.5% to 2% in leave-on formulations
- Regulatory status
- Approved as a cosmetic ingredient in the EU, US, and other major markets. Not classified as a drug, so anti-aging claims must be carefully worded.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- As a synthetic peptide, it is produced in controlled laboratory conditions, which reduces the environmental impact compared to harvesting from natural sources.
Good to know
- Peptides are often listed on labels as 'palmitoyl' or 'acetyl' followed by a number—SH-Polypeptide-97 is a newer addition to this family.
- It is compatible with most other skincare ingredients, including hyaluronic acid and niacinamide.
Common questions
What is SH-Polypeptide-97 in beauty products?
SH-Polypeptide-97 is a short chain of amino acids (the building blocks of protein) made in a lab. When applied to the skin in a cream or serum, it acts like a tiny messenger that tells skin cells to ramp up collagen production. More collagen means firmer, plumper skin and fewer fine lines over time. Because it's synthetic, it's very stable in formulas and unlikely to cause irritation.
What does SH-Polypeptide-97 do in a beauty product?
It binds to receptors on fibroblasts (the cells that make collagen) and signals them to produce more collagen and other structural proteins. This helps reinforce the skin's support network, reducing the appearance of wrinkles and improving elasticity.
Is SH-Polypeptide-97 safe for most people?
SH-Polypeptide-97 is considered safe for cosmetic use at typical concentrations. It has a low irritation and comedogenic profile, and no significant safety concerns have been reported in available literature.
Who should be careful with SH-Polypeptide-97?
Anyone allergic to synthetic peptides (rare) Those expecting immediate, dramatic results
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.