Ingredient review
SH-Polypeptide-67
INCI: SH-Polypeptide-67
SH-Polypeptide-67 is a lab-made peptide that may help reduce fine lines and support skin firmness, but human studies are limited.
In plain English
SH-Polypeptide-67 is a short chain of amino acids (the building blocks of protein) created in a lab. When applied to the skin, it signals cells to produce more collagen and elastin, which are the proteins that keep skin plump and firm. Think of it as a tiny messenger that tells your skin to act younger. It's commonly found in anti-aging serums and creams.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
SH-Polypeptide-67 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging SH-Polypeptide-67.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
SH-Polypeptide-67 is a synthetic peptide, meaning it's a man-made fragment of a protein. It belongs to a class of ingredients called signal peptides, which are designed to mimic natural peptides in the skin that trigger repair and renewal processes.
How it works
When applied topically, SH-Polypeptide-67 penetrates the outer layer of the skin and binds to receptors on fibroblasts (the cells that make collagen). This binding sends a signal to increase collagen and elastin production, helping to improve skin firmness, elasticity, and reduce the appearance of fine lines and wrinkles over time.
Pros
Targeted anti-aging action
Specifically designed to signal collagen production, which can help improve skin firmness and reduce fine lines over weeks of consistent use.
Generally well-tolerated
Synthetic peptides like SH-Polypeptide-67 have a low risk of irritation or clogging pores, making them suitable for most skin types, including sensitive skin.
Cons and cautions
Gradual results
Peptides work slowly; you may need to use a product for 8–12 weeks before seeing noticeable improvements in skin texture or firmness.
Limited independent research
Most evidence comes from ingredient manufacturers rather than large, independent human trials, so the strength of the claims is moderate.
Best for
- Adults looking for anti-aging support
- Those with fine lines or loss of firmness
Use caution if
- Individuals with known peptide allergies (rare)
- Those seeking immediate results (peptides work gradually)
Usage tips
Safety summary
SH-Polypeptide-67 is considered safe for topical cosmetic use at typical concentrations. Irritation and allergy are rare. No significant safety concerns have been reported in the literature.
Research notes
Evidence for SH-Polypeptide-67 is based on in vitro studies and some small clinical trials showing improvements in skin firmness and wrinkle depth. More large-scale, independent human studies would strengthen the evidence base.
Common label clues
- Typical concentration
- Typically used at 0.5% to 2% in leave-on formulations
- Regulatory status
- Approved as a cosmetic ingredient in the EU, US, and other major markets. It is not classified as a drug ingredient.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- As a synthetic peptide, it is produced in controlled lab conditions, which reduces environmental impact compared to animal-derived ingredients.
Good to know
- Peptides are fragile; avoid using them with very low pH (strong acids) in the same routine.
- SH-Polypeptide-67 is often combined with other peptides for a broader anti-aging effect.
Common questions
What is SH-Polypeptide-67 in beauty products?
SH-Polypeptide-67 is a short chain of amino acids (the building blocks of protein) created in a lab. When applied to the skin, it signals cells to produce more collagen and elastin, which are the proteins that keep skin plump and firm. Think of it as a tiny messenger that tells your skin to act younger. It's commonly found in anti-aging serums and creams.
What does SH-Polypeptide-67 do in a beauty product?
When applied topically, SH-Polypeptide-67 penetrates the outer layer of the skin and binds to receptors on fibroblasts (the cells that make collagen). This binding sends a signal to increase collagen and elastin production, helping to improve skin firmness, elasticity, and reduce the appearance of fine lines and wrinkles over time.
Is SH-Polypeptide-67 safe for most people?
SH-Polypeptide-67 is considered safe for topical cosmetic use at typical concentrations. Irritation and allergy are rare. No significant safety concerns have been reported in the literature.
Who should be careful with SH-Polypeptide-67?
Individuals with known peptide allergies (rare) Those seeking immediate results (peptides work gradually)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.