Ingredient review
Oligopeptide-107
INCI: Oligopeptide-107, SH-Oligopeptide-1
A synthetic peptide that signals skin to produce more collagen, helping reduce fine lines and improve firmness with minimal irritation risk.
In plain English
Oligopeptide-107 is a short chain of amino acids (the building blocks of protein) made in a lab. When applied to skin in a cream or serum, it acts like a messenger, telling skin cells to ramp up collagen production. More collagen means firmer, plumper skin and fewer visible fine lines. Because it's a large molecule, it works best when formulated with delivery systems that help it penetrate the outer layer of skin.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Oligopeptide-107 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Oligopeptide-107.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
A synthetic peptide, specifically a short chain of amino acids designed to mimic natural signaling molecules in the skin that stimulate collagen synthesis.
How it works
Oligopeptide-107 binds to receptors on fibroblasts (the cells that make collagen) and triggers a cascade of signals that increase collagen production. This helps strengthen the skin's structure, reduce the appearance of wrinkles, and improve elasticity over time.
Pros
Gentle anti-aging
Oligopeptide-107 stimulates collagen without the irritation common with retinoids, making it suitable for sensitive skin types.
Supports skin structure
By boosting collagen, it helps maintain skin firmness and elasticity, which can slow visible signs of aging.
Cons and cautions
Gradual results
Peptides work slowly; noticeable improvements in fine lines and firmness typically take 8–12 weeks of consistent use.
Formulation dependent
Its effectiveness relies on the product's ability to deliver the peptide deep enough into the skin, which varies by brand and formula.
Best for
- People looking for a gentle anti-aging ingredient
- Those with sensitive skin who cannot tolerate retinoids
- Anyone wanting to improve skin firmness and elasticity
Use caution if
- Those seeking immediate dramatic results (peptides work gradually)
- People with known allergies to synthetic peptides (rare)
Usage tips
Safety summary
Oligopeptide-107 is considered safe for topical use in cosmetics at typical concentrations. It has low irritation and sensitization potential based on available safety assessments.
Research notes
Clinical studies on similar peptides (e.g., Matrixyl) show moderate evidence for collagen stimulation and wrinkle reduction. Direct studies on Oligopeptide-107 are limited, but its mechanism is well-supported by peptide science.
Common label clues
- Typical concentration
- 0.001% to 0.1%
- Regulatory status
- Approved as a cosmetic ingredient in the EU, US, and other major markets. Not classified as a drug ingredient.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- Synthetically produced, so no direct impact on natural peptide sources. Biodegradability data is limited.
Good to know
- Oligopeptide-107 is often combined with other peptides like SH-Oligopeptide-1 for synergistic effects.
- It is stable in water-based formulas but may degrade in very low pH products.
Common questions
What is Oligopeptide-107 in beauty products?
Oligopeptide-107 is a short chain of amino acids (the building blocks of protein) made in a lab. When applied to skin in a cream or serum, it acts like a messenger, telling skin cells to ramp up collagen production. More collagen means firmer, plumper skin and fewer visible fine lines. Because it's a large molecule, it works best when formulated with delivery systems that help it penetrate the outer layer of skin.
What does Oligopeptide-107 do in a beauty product?
Oligopeptide-107 binds to receptors on fibroblasts (the cells that make collagen) and triggers a cascade of signals that increase collagen production. This helps strengthen the skin's structure, reduce the appearance of wrinkles, and improve elasticity over time.
Is Oligopeptide-107 safe for most people?
Oligopeptide-107 is considered safe for topical use in cosmetics at typical concentrations. It has low irritation and sensitization potential based on available safety assessments.
Who should be careful with Oligopeptide-107?
Those seeking immediate dramatic results (peptides work gradually) People with known allergies to synthetic peptides (rare)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.