Ingredient review
Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40
INCI: Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40
A novel plant-derived peptide complex that may help support collagen production, but research is still early and it's less proven than well-studied peptides.
In plain English
This ingredient is a custom blend of small protein fragments (peptides) made using a tobacco plant called Nicotiana benthamiana. In skincare, peptides act like signals that tell your skin cells to produce more collagen and elastin, which can help reduce fine lines and improve firmness. Because it's made in a lab using plant cells, it's considered a biotech ingredient. While promising, it's newer to the market, so there's less long-term research compared to classic peptides like Matrixyl or copper peptides.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is still emerging, so marketing claims deserve extra caution.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- biotech
- Evidence
- emerging
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
A synthetic peptide complex produced via biotechnology using Nicotiana benthamiana (a relative of tobacco) as a host organism. The SH-Polypeptide-15 and Hexapeptide-40 sequences are designed to mimic natural signaling peptides in human skin.
How it works
These peptides are thought to bind to receptors on skin cells, triggering signals that boost collagen and elastin synthesis. They may also help reduce the breakdown of existing collagen, leading to firmer, smoother skin over time.
Pros
Biotech origin is sustainable
Produced using plant-based biotechnology rather than animal-derived sources, making it a more sustainable and vegan-friendly peptide option.
Low irritation potential
Peptides in general are very gentle on skin, and this one is no exception — it's unlikely to cause stinging or redness, even for sensitive skin types.
Cons and cautions
Limited research
Unlike well-studied peptides like Matrixyl, this specific complex has fewer published human trials, so its effectiveness is less certain.
Premium price tag
Because it's a newer biotech ingredient, products containing it tend to be more expensive than those with traditional peptides.
Best for
- Anyone looking for a gentle anti-aging peptide option
- People with sensitive skin who want to avoid harsh actives
Use caution if
- Those who prefer ingredients with extensive clinical backing
Usage tips
Safety summary
Considered safe for topical cosmetic use at typical concentrations. The ingredient is non-irritating and non-sensitizing in standard tests. However, as with any new ingredient, patch testing is recommended for those with extremely reactive skin.
Research notes
Research on this specific peptide complex is still emerging. Most evidence comes from in vitro (lab) studies and manufacturer-sponsored trials. While the mechanism is plausible based on known peptide science, independent peer-reviewed human studies are limited.
Common label clues
- Typical concentration
- Typically 0.1% to 1% in leave-on products
- Regulatory status
- Approved for cosmetic use in the EU, US, and other major markets as a skin conditioning agent. No specific restrictions beyond general cosmetic safety requirements.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- The biotech production method using plant cell cultures is generally more environmentally friendly than traditional extraction from animal or plant sources, as it requires less land and water.
Good to know
- Despite the tobacco plant origin, the final ingredient is highly purified and does not contain nicotine or other tobacco alkaloids.
- It is often combined with other anti-aging ingredients like niacinamide or hyaluronic acid in formulations.
Common questions
What is Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40 in beauty products?
This ingredient is a custom blend of small protein fragments (peptides) made using a tobacco plant called Nicotiana benthamiana. In skincare, peptides act like signals that tell your skin cells to produce more collagen and elastin, which can help reduce fine lines and improve firmness. Because it's made in a lab using plant cells, it's considered a biotech ingredient. While promising, it's newer to the market, so there's less long-term research compared to classic peptides like Matrixyl or copper peptides.
What does Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40 do in a beauty product?
These peptides are thought to bind to receptors on skin cells, triggering signals that boost collagen and elastin synthesis. They may also help reduce the breakdown of existing collagen, leading to firmer, smoother skin over time.
Is Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40 safe for most people?
Considered safe for topical cosmetic use at typical concentrations. The ingredient is non-irritating and non-sensitizing in standard tests. However, as with any new ingredient, patch testing is recommended for those with extremely reactive skin.
Who should be careful with Nicotiana Benthamiana SH-Polypeptide-15 Hexapeptide-40?
Those who prefer ingredients with extensive clinical backing
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.