Ingredient review
Natamycin
INCI: Natamycin
Natamycin is a gentle, naturally derived preservative that fights fungi and yeast, making it a good option for sensitive skin formulas.
In plain English
Natamycin is a natural substance produced by bacteria that stops fungi and yeast from growing. In skincare, it's used as a preservative to keep products fresh and safe without harsh chemicals. It's especially helpful for people with sensitive skin who react to common preservatives like parabens or formaldehyde releasers.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- natural
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Natamycin is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Natamycin.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
Natamycin is a polyene macrolide antifungal agent naturally produced by the bacterium Streptomyces natalensis. It is commonly used in the food industry (e.g., on cheese rinds) and in cosmetics as a preservative.
How it works
Natamycin works by binding to ergosterol, a key component of fungal cell membranes, causing them to become leaky and eventually killing the fungi. This prevents spoilage and extends the shelf life of cosmetic products without affecting bacteria.
Pros
Gentle on skin
Natamycin has a very low irritation risk, making it suitable for sensitive skin and eye-area products.
Natural origin
Derived from a natural fermentation process, it appeals to consumers seeking 'clean' or naturally derived ingredients.
Cons and cautions
Narrow antimicrobial spectrum
Natamycin only targets fungi and yeast, so it must be combined with other preservatives to protect against bacteria, which can complicate formulations.
Higher cost
Because it's produced via fermentation, natamycin is more expensive than many synthetic preservatives, potentially raising product prices.
Best for
- People with sensitive or reactive skin
- Those looking for natural or gentle preservative options
Use caution if
- Anyone with a known allergy to natamycin (rare)
Usage tips
Safety summary
Natamycin is considered safe for use in cosmetics at typical concentrations. It has low skin irritation and sensitization potential, and no known systemic toxicity when used topically.
Research notes
Studies confirm natamycin's efficacy against a wide range of fungi and its low irritation profile. It is well-established in food preservation and increasingly used in cosmetics as a gentle alternative.
Common label clues
- Typical concentration
- 0.01% to 0.05%
- Regulatory status
- Approved as a food additive and cosmetic preservative in many regions, including the EU and US. In the EU, it is listed in Annex V of the Cosmetics Regulation.
- Common uses
- Preserved creams, Lotions, Eye area products
- Environmental note
- Produced via fermentation, natamycin is biodegradable and considered environmentally friendly compared to some synthetic preservatives.
Good to know
- Natamycin is also used in the food industry, especially on cheese, and is generally recognized as safe (GRAS) by the FDA.
- It is not absorbed through intact skin, so it stays on the surface where it's needed.
Common questions
What is Natamycin in beauty products?
Natamycin is a natural substance produced by bacteria that stops fungi and yeast from growing. In skincare, it's used as a preservative to keep products fresh and safe without harsh chemicals. It's especially helpful for people with sensitive skin who react to common preservatives like parabens or formaldehyde releasers.
What does Natamycin do in a beauty product?
Natamycin works by binding to ergosterol, a key component of fungal cell membranes, causing them to become leaky and eventually killing the fungi. This prevents spoilage and extends the shelf life of cosmetic products without affecting bacteria.
Is Natamycin safe for most people?
Natamycin is considered safe for use in cosmetics at typical concentrations. It has low skin irritation and sensitization potential, and no known systemic toxicity when used topically.
Who should be careful with Natamycin?
Anyone with a known allergy to natamycin (rare)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.