Ingredient review
Myristoyl Tetrapeptide-13
INCI: Myristoyl Tetrapeptide-13
A synthetic peptide that may help improve skin firmness and reduce fine lines, with low irritation potential.
In plain English
Myristoyl Tetrapeptide-13 is a lab-made peptide (a small chain of amino acids) that is added to skincare products to help support the skin's structure. It works by signaling skin cells to produce more collagen and other supportive proteins, which can make the skin look firmer and smoother over time. Because it is used in very small amounts, it is generally gentle and unlikely to cause irritation.
Review score
Safety, usefulness, and evidence
Potentially useful with some tradeoffs
The evidence base is useful, but some claims depend heavily on the formula.
Risk flags are low for most users, though the finished product can still irritate.
- Source
- synthetic
- Evidence
- moderate
- Irritation
- low
- Clogging risk
- low
Quick decision guide
Useful, but context matters
Myristoyl Tetrapeptide-13 is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Myristoyl Tetrapeptide-13.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
moderateThere is useful support, but formula details and claim strength still matter.
What it is
Myristoyl Tetrapeptide-13 is a synthetic peptide, meaning it is a short chain of amino acids created in a laboratory. It is designed to mimic naturally occurring peptides in the skin that signal cells to build collagen and elastin.
How it works
When applied topically, the peptide is thought to bind to receptors on skin cells and trigger a cascade of signals that encourage the production of collagen and other extracellular matrix components. This can help improve skin firmness, elasticity, and reduce the appearance of fine lines and wrinkles over time.
Pros
Gentle anti-aging support
Myristoyl Tetrapeptide-13 is generally non-irritating and suitable for sensitive skin, making it a good option for those who cannot tolerate stronger anti-aging ingredients like retinoids.
Targets skin structure
By signaling collagen production, this peptide addresses the underlying support structure of the skin, which can lead to firmer, more resilient skin over time.
Cons and cautions
Slow, gradual results
Unlike some active ingredients that provide immediate surface effects, this peptide works slowly by influencing cell behavior, so visible improvements may take several weeks of consistent use.
Limited independent research
While peptide technology is well-studied overall, specific data on Myristoyl Tetrapeptide-13 alone is less abundant, and most evidence comes from manufacturer studies.
Best for
- Adults looking to improve skin firmness and reduce signs of aging
- Those with sensitive skin seeking a gentle anti-aging ingredient
Use caution if
- Individuals with known allergies to peptides or specific amino acids
Usage tips
Safety summary
Myristoyl Tetrapeptide-13 is considered safe for use in cosmetics at typical concentrations. It has low irritation and comedogenic potential, and no significant safety concerns have been reported in the literature.
Research notes
Peptides in general have moderate evidence supporting their ability to stimulate collagen production and improve skin firmness. Specific studies on Myristoyl Tetrapeptide-13 are limited, but the mechanism is well-understood and supported by broader peptide research.
Common label clues
- Typical concentration
- 0.001% to 0.1%
- Regulatory status
- Approved for use in cosmetics in the US, EU, and other major markets. No known restrictions at typical use levels.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- As a synthetic peptide, it is produced through chemical synthesis, which has a lower environmental footprint compared to animal-derived ingredients, but the production process still requires energy and resources.
Good to know
- Peptides are often combined with other anti-aging ingredients like niacinamide or hyaluronic acid for synergistic benefits.
- The 'myristoyl' part refers to a fatty acid chain attached to the peptide, which helps it penetrate the skin more effectively.
Common questions
What is Myristoyl Tetrapeptide-13 in beauty products?
Myristoyl Tetrapeptide-13 is a lab-made peptide (a small chain of amino acids) that is added to skincare products to help support the skin's structure. It works by signaling skin cells to produce more collagen and other supportive proteins, which can make the skin look firmer and smoother over time. Because it is used in very small amounts, it is generally gentle and unlikely to cause irritation.
What does Myristoyl Tetrapeptide-13 do in a beauty product?
When applied topically, the peptide is thought to bind to receptors on skin cells and trigger a cascade of signals that encourage the production of collagen and other extracellular matrix components. This can help improve skin firmness, elasticity, and reduce the appearance of fine lines and wrinkles over time.
Is Myristoyl Tetrapeptide-13 safe for most people?
Myristoyl Tetrapeptide-13 is considered safe for use in cosmetics at typical concentrations. It has low irritation and comedogenic potential, and no significant safety concerns have been reported in the literature.
Who should be careful with Myristoyl Tetrapeptide-13?
Individuals with known allergies to peptides or specific amino acids
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.