Ingredient review

Dechloro Cyclopropylmethylcloprostenolamide

INCI: DECHLORO CYCLOPROPYLMETHYLCLOPROSTENOLAMIDE

A synthetic prostaglandin analog that may help with hair growth, but evidence is limited and irritation is possible.

beautyskincarehair care

In plain English

This is a lab-made ingredient that mimics a natural compound called prostaglandin, which plays a role in hair growth. It's used in some hair serums and scalp treatments, but it's still new and not well-studied in cosmetics. Because it's potent, it's used in very tiny amounts and can cause redness or stinging for some people.

Review score

Safety, usefulness, and evidence

3.0Fair
3.0/ 5

Useful in the right context, but not low-maintenance

The evidence base is still emerging, so marketing claims deserve extra caution.

Main practical flags: irritation is moderate; clogging risk is low.

Source
synthetic
Evidence
emerging
Irritation
moderate
Clogging risk
low
How reviews are scored

Quick decision guide

Read the cautions before using

Dechloro Cyclopropylmethylcloprostenolamide can be useful, but watch for some irritation potential.

Plain-English read

Treat this as a practical screening step before you compare products that contain this ingredient.

  1. Step 1Start with the score, then check the irritation and clogging risk before judging Dechloro Cyclopropylmethylcloprostenolamide.
  2. Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
  3. Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.

Score terms in plain English

Irritation risk

moderate

Can bother some users, especially with frequent use, damaged skin, or strong companion ingredients.

Clogging risk

low

Less likely to feel heavy or contribute to clogged pores for most skin types.

Evidence level

emerging

The ingredient may be promising, but claims should be treated more cautiously.

What it is

A synthetic analog of prostaglandin F2α, modified to remove a chlorine atom and add a cyclopropylmethyl group, intended to stimulate hair follicles.

How it works

It is thought to bind to prostaglandin receptors on hair follicle cells, potentially prolonging the anagen (growth) phase of the hair cycle and increasing hair density.

Pros

Novel mechanism

Targets prostaglandin receptors differently than common hair growth ingredients, offering a new approach for hair density.

Low comedogenic risk

Unlikely to clog pores, making it suitable for scalp use without causing acne.

Cons and cautions

Limited safety data

There are few published studies on its long-term safety in cosmetic products, so the full risk profile is unknown.

Potential irritation

As a potent synthetic compound, it may cause redness, itching, or stinging on sensitive scalps.

Best for

  • People with thinning hair looking for experimental options
  • Those who have tried standard treatments without success

Use caution if

  • People with sensitive scalps
  • Pregnant or nursing individuals
  • Those with a history of skin allergies

Usage tips

Start with a patch test on a small area of scalp before full application.
Use only as directed on the product label, typically once daily.
Avoid applying to broken or irritated skin.

Safety summary

Safety data is limited. It may cause scalp irritation in some users. Pregnant or nursing individuals should avoid it due to lack of safety studies.

Research notes

There are few peer-reviewed studies on this specific analog in cosmetics. Most evidence comes from related prostaglandin analogs used in medical treatments for glaucoma and eyelash growth.

Common label clues

Typical concentration
Very low, typically under 0.1%
Regulatory status
Not specifically approved by the FDA for cosmetic use; regulated as a cosmetic ingredient in the US, but safety data is limited.
Common uses
Hair serums, Scalp treatments
Environmental note
Synthetic production may involve chemical waste; no specific environmental impact data available.

Good to know

  • This ingredient is not the same as cloprostenol, which is used in veterinary medicine.
  • It is often found in very low concentrations due to its potency.

Common questions

What is Dechloro Cyclopropylmethylcloprostenolamide in beauty products?

This is a lab-made ingredient that mimics a natural compound called prostaglandin, which plays a role in hair growth. It's used in some hair serums and scalp treatments, but it's still new and not well-studied in cosmetics. Because it's potent, it's used in very tiny amounts and can cause redness or stinging for some people.

What does Dechloro Cyclopropylmethylcloprostenolamide do in a beauty product?

It is thought to bind to prostaglandin receptors on hair follicle cells, potentially prolonging the anagen (growth) phase of the hair cycle and increasing hair density.

Is Dechloro Cyclopropylmethylcloprostenolamide safe for most people?

Safety data is limited. It may cause scalp irritation in some users. Pregnant or nursing individuals should avoid it due to lack of safety studies.

Who should be careful with Dechloro Cyclopropylmethylcloprostenolamide?

People with sensitive scalps Pregnant or nursing individuals Those with a history of skin allergies

Research sources

PubMed - Prostaglandin analogs in hair growthOpenCosmetic Ingredient Review - Safety guidelinesOpen

Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.