Ingredient review
Aminobenzoyl Tripeptide-39 Hydroxamic Acid
INCI: Aminobenzoyl Tripeptide-39 Hydroxamic Acid
A synthetic peptide that may help reduce fine lines and improve skin firmness by interfering with collagen-degrading enzymes.
In plain English
This is a lab-made peptide (a small chain of amino acids) designed to help your skin look firmer and smoother. It works by blocking certain enzymes that break down collagen, the protein that keeps skin plump and youthful. Think of it as a gentle signal to your skin to hold onto its structure longer.
Quick decision guide
Useful, but context matters
Aminobenzoyl Tripeptide-39 Hydroxamic Acid is generally a lower-concern ingredient when the full formula suits your skin.
Plain-English read
Treat this as a practical screening step before you compare products that contain this ingredient.
- Step 1Start with the score, then check the irritation and clogging risk before judging Aminobenzoyl Tripeptide-39 Hydroxamic Acid.
- Step 2Use the "Best for" and "Use caution if" sections to match the ingredient to your skin, not just to a marketing claim.
- Step 3If a product stings, breaks you out, or worsens irritation, judge the finished formula and stop using it even if the ingredient scores well.
Score terms in plain English
Irritation risk
lowLess likely to sting, burn, or bother most users, though sensitive skin can still react.
Clogging risk
lowLess likely to feel heavy or contribute to clogged pores for most skin types.
Evidence level
emergingThe ingredient may be promising, but claims should be treated more cautiously.
What it is
A synthetic peptide modified with a hydroxamic acid group, which gives it the ability to bind to and inhibit matrix metalloproteinases (MMPs) — enzymes that degrade collagen and elastin in the skin.
How it works
When applied topically, the peptide penetrates the outer skin layer and binds to MMPs, reducing their activity. This helps preserve existing collagen and elastin, potentially slowing the formation of wrinkles and maintaining skin firmness over time.
Pros
Targets collagen breakdown
Unlike many peptides that only stimulate collagen production, this one also helps protect existing collagen by inhibiting enzymes that break it down.
Low irritation potential
Synthetic peptides are generally well-tolerated, making this a good option for sensitive skin that cannot tolerate stronger anti-aging actives like retinol.
Cons and cautions
Emerging evidence
While the mechanism is promising, there are fewer published human studies on this specific peptide compared to more established anti-aging ingredients.
Results take time
Like most peptides, visible improvements in firmness and wrinkles typically require consistent use over several weeks to months.
Best for
- Anyone looking for a gentle anti-aging ingredient
- People with early signs of aging who want to maintain skin firmness
Use caution if
- Those with known allergies to synthetic peptides (rare)
Usage tips
Safety summary
Considered safe for topical cosmetic use at typical concentrations. No significant irritation or sensitization has been reported in available studies. As with any new ingredient, patch testing is recommended for those with very sensitive skin.
Research notes
The mechanism of MMP inhibition is supported by in vitro studies, but clinical data on this specific peptide is limited. It is part of a newer generation of peptide technologies that show promise for anti-aging applications.
Common label clues
- Typical concentration
- Typically used at 0.1–1% in leave-on formulations
- Regulatory status
- Approved for cosmetic use in the EU, US, and other major markets as a skin-conditioning agent. Not classified as a drug.
- Common uses
- Anti-aging serums, Firming creams, Eye treatments
- Environmental note
- Synthetic peptides are produced in controlled lab settings, which reduces environmental impact compared to animal-derived ingredients, but their biodegradability is not well studied.
Good to know
- This peptide is often found in higher-end anti-aging serums and may be listed under its full INCI name on ingredient labels.
- It is stable in most formulations but avoid combining with very low pH products (like strong AHAs) immediately before application.
Common questions
What is Aminobenzoyl Tripeptide-39 Hydroxamic Acid in beauty products?
This is a lab-made peptide (a small chain of amino acids) designed to help your skin look firmer and smoother. It works by blocking certain enzymes that break down collagen, the protein that keeps skin plump and youthful. Think of it as a gentle signal to your skin to hold onto its structure longer.
What does Aminobenzoyl Tripeptide-39 Hydroxamic Acid do in a beauty product?
When applied topically, the peptide penetrates the outer skin layer and binds to MMPs, reducing their activity. This helps preserve existing collagen and elastin, potentially slowing the formation of wrinkles and maintaining skin firmness over time.
Is Aminobenzoyl Tripeptide-39 Hydroxamic Acid safe for most people?
Considered safe for topical cosmetic use at typical concentrations. No significant irritation or sensitization has been reported in available studies. As with any new ingredient, patch testing is recommended for those with very sensitive skin.
Who should be careful with Aminobenzoyl Tripeptide-39 Hydroxamic Acid?
Those with known allergies to synthetic peptides (rare)
Research sources
Ingredient reviews are educational and are not medical advice. Patch test new products and ask a licensed clinician about persistent irritation, allergies, pregnancy-specific questions, or diagnosed skin conditions.